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  1. No Access

    Article

    Toying with reductive stress

    Genetically encoded tools to manipulate redox metabolism are in high demand for investigating the underlying mechanism of cofactor imbalances in mammalian systems. A new tool enables the induction and interrog...

    Alexandria C. Murphy, Melanie R. McReynolds in Nature Chemical Biology (2024)

  2. No Access

    Article

    TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models

    Human genetics implicate defective myeloid responses in the development of late-onset Alzheimer disease. A decline in peripheral and brain myeloid metabolism, triggering maladaptive immune responses, is a feat...

    Edward N. Wilson, Congcong Wang, Michelle S. Swarovski… in Nature Neuroscience (2024)

  3. Article

    Open Access

    mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses

    Translocated lipopolysaccharide (LPS) activates monocytes via TLR4 and is hypothesized to increase cardiovascular disease risk in persons living with HIV. We tested whether mTOR activity supports LPS-stimulate...

    Nina C. Lund, Yetunde Kayode, Melanie R. McReynolds… in Communications Biology (2022)

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    Article

    Spatially resolved isotope tracing reveals tissue metabolic activity

    Isotope tracing has helped to determine the metabolic activities of organs. Methods to probe metabolic heterogeneity within organs are less developed. We couple stable-isotope-labeled nutrient infusion to matr...

    Lin Wang, ** **ng, **anfeng Zeng, S. RaElle Jackson, Tara TeSlaa… in Nature Methods (2022)

  5. No Access

    Article

    Metabolite discovery through global annotation of untargeted metabolomics data

    Liquid chromatography–high-resolution mass spectrometry (LC-MS)-based metabolomics aims to identify and quantify all metabolites, but most LC-MS peaks remain unidentified. Here we present a global network opti...

    Li Chen, Wenyun Lu, Lin Wang, ** **ng, Ziyang Chen, **n Teng… in Nature Methods (2021)

  6. No Access

    Article

    Restoring metabolism of myeloid cells reverses cognitive decline in ageing

    Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1–3. The ageing brain is also vulnerable to inflammati...

    Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds… in Nature (2021)

  7. Article

    The art of virtual mentoring in the twenty-first century for STEM majors and beyond

    Social quarantine has severely impacted the training of new scientists, but the use of virtual platforms can supplement mentorship, making career development seamless.

    Melanie R. McReynolds, Christina M. Termini, Antentor O. Hinton Jr… in Nature Biotechnology (2020)

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  8. No Access

    Article

    SLC25A51 is a mammalian mitochondrial NAD+ transporter

    Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been ident...

    Timothy S. Luongo, Jared M. Eller, Mu-Jie Lu, Marc Niere, Fabio Raith… in Nature (2020)

  9. No Access

    Article

    CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

    Decreased NAD+ levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated du...

    Claudia C. S. Chini, Thais R. Peclat, Gina M. Warner, Sonu Kashyap… in Nature Metabolism (2020)