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Article
Open AccessFurther evidence supporting a potential role for ADH1B in obesity
Insulin is an essential hormone that regulates glucose homeostasis and metabolism. Insulin resistance (IR) arises when tissues fail to respond to insulin, and it leads to serious health problems including Type...
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Article
DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes
Metabolic memory, the persistent benefits of early glycaemic control on preventing and/or delaying the development of diabetic complications, has been observed in the Diabetes Control and Complications Trial (...
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Article
A genome-wide analysis of 'Bounty' descendants implicates several novel variants in migraine susceptibility
Migraine is a common neurological disease with a complex genetic aetiology. The disease affects ~12 % of the Caucasian population and females are three times more likely than males to be diagnosed. In an effor...
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Article
Open AccessVariants in the human potassium channel gene (KCNN3) are associated with migraine in a high risk genetic isolate
The calcium-activated potassium ion channel gene (KCNN3) is located in the vicinity of the familial hemiplegic migraine type 2 locus on chromosome 1q21.3. This gene is expressed in the central nervous system a...
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Article
Hepatic Gene Networks in Morbidly Obese Patients With Nonalcoholic Fatty Liver Disease
Genetic factors alter the risk for nonalcoholic fatty liver disease (NAFLD). We sought to identify NAFLD-associated genes and elucidate gene networks and pathways involved in the pathogenesis of NAFLD.
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Protocol
Analysis of Genomic Aberrations Using Comparative Genomic Hybridization of Metaphase Chromosomes
Comparative genomic hybridization (CGH) allows the global screening of copy number aberrations within a sample. Specifically, large (>20 mb) deletions and amplifications are detected, which are likely to indic...
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Protocol
Investigation of Genomic Methylation Status Using Methylation-Specific and Bisulfite Sequencing Polymerase Chain Reaction
Epigenetic modification plays a central role in the regulation of gene expression and therefore in the development of disease states. In particular, genomic methylation of cytosines within CpG dinucleotides is...
