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  1. No Access

    Article

    Lysosomal cation channel TRPML1 suppression sensitizes acute myeloid leukemia cells to chemotherapeutics by inhibiting autophagy

    Despite the implementation of novel therapeutic regimens and extensive research efforts, chemoresistance remains a formidable challenge in the treatment of acute myeloid leukemia (AML). Notably, the involvemen...

    Meifang Dai, Bingqian Lin, Hao Li, Youming Wang… in Molecular and Cellular Biochemistry (2024)

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    Article

    Metabolomic profiling of single enlarged lysosomes

    Lysosomes are critical for cellular metabolism and are heterogeneously involved in various cellular processes. The ability to measure lysosomal metabolic heterogeneity is essential for understanding their phys...

    Hongying Zhu, Qianqian Li, Tiepeng Liao, **ang Yin, Qi Chen, Ziyi Wang… in Nature Methods (2021)

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    Article

    A genetic investigation of E2A function in lymphocyte development

    Lymphocytes are derived from hematopoietic stem cells (HSC) following a series of regulated differentiation events. Multipotent HSCs become committed to the B cell lineage in bone marrow and the T cell lineage...

    Jenifer Hanrahan, Lihua Pan, Stephen Greenbaum, Curtis Bradney… in Immunologic Research (2000)