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Article
LncRNA BBOX1-AS1 Contributes to Laryngeal Carcinoma Progression by Recruiting SRSF1 to Maintain EFNB2 mRNA Stability
Laryngeal cancer is a common malignancy of the larynx with a generally poor prognosis. This study systematically assessed the functional role of lncRNA BBOX1-AS1 in laryngeal carcinoma progression and associat...
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Article
Open AccessSemantic embedding based online cross-modal hashing method
Hashing has been extensively utilized in cross-modal retrieval due to its high efficiency in handling large-scale, high-dimensional data. However, most existing cross-modal hashing methods operate as offline l...
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Article
Open AccessSulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish
Nonsteroidal anti-inflammatory drugs compose one of the most widely used classes of medications, but the risks for early development remain controversial, especially in the nervous system. Here, we utilized ze...
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Article
A critical review on thermodynamic mechanisms of membrane fouling in membrane-based water treatment process
Membrane technology is widely regarded as one of the most promising technologies for wastewater treatment and reclamation in the 21st century. However, membrane fouling significantly limits its applicability a...
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Article
Open AccessCaloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota
Caloric restriction (CR) has been known to promote health by reprogramming metabolism, yet little is known about how the epigenome and microbiome respond during metabolic adaptation to CR.
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Article
Open AccessRA-RAR signaling promotes mouse vaginal opening through increasing β-catenin expression and vaginal epithelial cell apoptosis
Retinoic acid (RA) plays important role in the maintenance and differentiation of the Müllerian ducts during the embryonic stage via RA receptors (RARs). However, the function and mechanism of RA-RAR signaling...
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Article
Open AccessThe oocyte cumulus complex regulates mouse sperm migration in the oviduct
As the time of ovulation draws near, mouse spermatozoa move out of the isthmic reservoir, which is a prerequisite for fertilization. However, the molecular mechanism remains unclear. The present study revealed...
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Article
Open AccessSphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation
Germ cell division and differentiation require intimate contact and interaction with the surrounding somatic cells. Luteinizing hormone (LH) triggers epidermal growth factor (EGF)-like growth factors to promot...
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Article
Open AccessEnhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling
In mammals, nonrenewable primordial follicles are activated in an orderly manner to maintain the longevity of reproductive life. Mammalian target of rapamycin (mTOR)-KIT ligand (KITL) signaling in pre-granulos...
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Article
Open AccessSgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development
Sphingosine phosphate lyase 1 (SGPL1) is a highly conserved enzyme that irreversibly degrades sphingosine-1-phosphate (S1P). Sgpl1-knockout mice fail to develop germ cells, resulting in infertility. However, the ...
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Article
CREB activity is required for mTORC1 signaling-induced primordial follicle activation in mice
In mammals, progressive activation of primordial follicles is essential for maintenance of the reproductive lifespan. Several reports have demonstrated that mitogen-activated protein kinases 3 and 1 (MAPK3/1)–...
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Article
Multi-modal graph regularization based class center discriminant analysis for cross modal retrieval
On the network, a large amount of multi-modal data has emerged. Efficiently utilizing such data to conduct cross modal retrieval has become a hot topic of research. Some solutions have been proposed for this p...
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Article
Open AccessTransforming growth factor-β is involved in maintaining oocyte meiotic arrest by promoting natriuretic peptide type C expression in mouse granulosa cells
Natriuretic peptide type C (NPPC) secreted by mural granulosa cells (MGCs) maintains oocyte meiotic arrest via the activation of guanylyl cyclase-linked natriuretic peptide receptor 2 (NPR2). Here, we investig...
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Article
Open AccessNatriuretic peptide type C induces sperm attraction for fertilization in mouse
Mammalian spermatozoa undergo selective movement along the isthmus of the oviduct to the ampulla during ovulation, which is a prerequisite for fertilization. The factor(s) that involves in selective spermatozo...
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Article
Open AccessA novel insight into membrane fouling mechanism regarding gel layer filtration: Flory-Huggins based filtration mechanism
This study linked the chemical potential change to high specific filtration resistance (SFR) of gel layer, and then proposed a novel membrane fouling mechanism regarding gel layer filtration, namely, Flory-Hug...
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Article
Hormonal control of mammalian oocyte meiosis at diplotene stage
Mammalian oocytes grow and undergo meiosis within ovarian follicles. Fully grown oocytes are arrested at the first meiotic prophase by a mural granulosa origin “arrester” until a surge of luteinizing hormone (...
