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Article
TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway
Macrophage lipid accumulation is a critical contributor to foam cell formation and atherosclerosis. Tumor necrosis factor-α-induced protein 1 (TNFAIP1) is closely associated with cardiovascular disease. Howeve...
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Article
Wave propagation and free vibration of a Timoshenko beam mounted on the viscoelastic Pasternak foundation modeled by fraction-order derivatives
There is a second frequency spectrum existing for the classic Timoshenko beam with hinged supports at both ends. However, it is usually assumed that the second frequency spectrum is unphysical. In this paper, ...
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Article
A general strategy for MOFs coupled to optical fiber for highly sensitive humidity sensing
To achieve real-time and high-sensitive humidity sensing, a universal method was developed to allow arbitrary nanocrystals to be attached to the end of an optical fiber, further producing an effective interfer...
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Article
Open AccessDietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis
T cell development requires the coordinated rearrangement of T cell receptor (TCR) gene segments and the expression of either αβ or γδ TCR. However, whether and how de novo synthesis of nutrients contributes t...
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Article
Relationships Between Dietary Patterns and Low-Level Lead Exposure Among Children from Hunan Province of China
Lead (Pb) is a potent environmental toxic metal. Few studies have focused on low-level Pb exposure in children. This study evaluated the relationships of dietary patterns with low-level Pb exposure in children...
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Article
Shenqi Fuzheng Injection (参芪扶**注射液) Combined with Chemotherapy for Acute Leukemia: A Meta-Analysis
To evaluate to the efficacy and safety of Shenqi Fuzheng Injection (参芪扶**注射液, SFI) combined with chemotherapy in the treatment of acute leukemia (AL) by meta-analysis.
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Article
Open AccessIRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
Enterovirus 71 (EV71) poses serious threats to human health, particularly in Southeast Asia, and no drugs or vaccines are available. Previous work identified the stem loop II structure of the EV71 internal rib...
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Article
Growth of Gallium Nitride Films on Multilayer Graphene Template Using Plasma-Enhanced Atomic Layer Deposition
In this work, the GaN thin films were directly deposited on multilayer graphene (MLG) by plasma-enhanced atomic layer deposition. The deposition was carried out at a low temperature using triethylgallium (TEGa...
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Article
Numerical Investigation of In-Flight Behavior of Fe-Based Amorphous Alloy Particles in AC-HVAF Thermal Spray Process
Computational fluid dynamics is used to investigate the in-flight behavior of particles of Fe-based amorphous alloy powder in an activated combustion high-velocity air fuel spray process. The continuity, momen...
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Article
Open AccessReliable Attention Network Scores and Mutually Inhibited Inter-network Relationships Revealed by Mixed Design and Non-orthogonal Method
The attention system can be divided into alerting, orienting and executive control networks. The efficiency and independence of attention networks have been widely tested with the attention network test (ANT) ...
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Article
Open AccesshnRNP A1 interacts with the genomic and subgenomic RNA promoters of Sindbis virus and is required for the synthesis of G and SG RNA
Sindbis virus (SV) is the prototype of alphaviruses which are a group of widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein that shuttle...
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Article
Novel mutations in the connexin43 (GJA1) and GJA1 pseudogene may contribute to nonsyndromic hearing loss
Connexins (CXs), a large family of membrane proteins, are key components of gap junction channels. Among a cohort of patients with nonsyndromic hearing loss, we have recently identified three novel missense mu...
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Article
Viral protein synthesis is required for Enterovirus 71 to induce apoptosis in human glioblastoma cells
Human glioblastoma cells (SF268) develop apoptosis, as characterized by DNA fragmentation and caspase activation, upon infection with Enterovirus 71 (EV71). To determine the step in virus replication that trig...
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Article
Diverse apoptotic pathways in enterovirus 71-infected cells
Mechanisms related to the neuropathogenesis of enterovirus 71 infection remain unclear. This investigation conducts a comprehensive study of the apoptotic pathways in neural and non-neural cells following ente...
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Article
Identification of genes involved in the host response to enterovirus 71 infection
Enterovirus 71 (EV71) infection may be asymptomatic or may cause diarrhea, rashes, and hand, foot, and mouth disease (HFMD). However, EV71 also has the potential to cause severe neurological disease. To date, ...
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Article
Mutations at KFRDI and VGK domains of enterovirus 71 3C protease affect its RNA binding and proteolytic activities
The 3C proteases (3Cpro) of enterovirus 71 (EV71) is a good molecular target for drug discovery. Notably, this protease was found to possess RNA-binding activity. The regions responsible for RNA binding were clas...
