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  1. No Access

    Article

    DNA mismatch and damage patterns revealed by single-molecule sequencing

    Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other diseases1,2. Most mutations begin as nucleotide mismatches or damage in one of the two strands of the DNA bef...

    Mei Hong Liu, Benjamin M. Costa, Emilia C. Bianchini, Una Choi, Rachel C. Bandler… in Nature (2024)

  2. Article

    Open Access

    Single duplex DNA sequencing with CODEC detects mutations with high sensitivity

    Detecting mutations from single DNA molecules is crucial in many fields but challenging. Next-generation sequencing (NGS) affords tremendous throughput but cannot directly sequence double-stranded DNA molecule...

    ** H. Bae, Ruolin Liu, Eugenia Roberts, Erica Nguyen, Shervin Tabrizi… in Nature Genetics (2023)

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  3. No Access

    Article

    Cortex-dependent corrections as the tongue reaches for and misses targets

    Precise tongue control is necessary for drinking, eating and vocalizing1–3. However, because tongue movements are fast and difficult to resolve, neural control of lingual kinematics remains poorly understood. Her...

    Tejapratap Bollu, Brendan S. Ito, Samuel C. Whitehead, Brian Kardon, James Redd… in Nature (2021)