-
Article
Open AccessCD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites
Children in malaria-endemic regions can experience repeated Plasmodium infections over short periods of time. Effects of re-infection on multiple co-existing CD4+ T cell subsets remain unresolved. Here, we examin...
-
Article
Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
-
Article
Open AccessSingle cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets
Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell subsets, which protects from immunopathogenesis, but also hampers the development of effective anti-parasitic immunity. Underst...
-
Article
Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory
The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its cessation and associates with effects on CD4+
-
Article
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we sh...
