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Open AccessConvergent somatic evolution commences in utero in a germline ribosomopathy
Clonal tracking of cells using somatic mutations permits exploration of clonal dynamics in human disease. Here, we perform whole genome sequencing of 323 haematopoietic colonies from 10 individuals with the in...
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Article
Open AccessSaving time and money in biomedical publishing: the case for free-format submissions with minimal requirements
Manuscript preparation and the (re)submission of articles can create a significant workload in academic jobs. In this exploratory analysis, we estimate the time and costs needed to meet the diverse formatting ...
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Article
Open AccessExploring resident experiences of person-centred care at mealtimes in long-term residential care: a rapid ethnography
Poor nutrition is a common ongoing problem in long-term residential care, often resulting in reduced quality of life. Previous research has concluded that the content of the meal, dining environment, service s...
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Individual and contextual predictors of overweight or obesity among women in Uganda: a spatio-temporal perspective
Being overweight and obesity are emerging public health issues in sub-Saharan Africa. Currently, there is limited knowledge on the temporal trend of the effect of socioeconomic factors and air quality on being...
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Article
Open AccessDiverse mutational landscapes in human lymphocytes
The lymphocyte genome is prone to many threats, including programmed mutation during differentiation1, antigen-driven proliferation and residency in diverse microenvironments. Here, after develo** protocols for...
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Article
Open AccessClonal dynamics of haematopoiesis across the human lifespan
Age-related change in human haematopoiesis causes reduced regenerative capacity1, cytopenias2, immune dysfunction3 and increased risk of blood cancer4–6, but the reason for such abrupt functional decline after 70...
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Article
Open AccessCross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts
Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses...
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Long-Term Care Staff Perceptions of Providing Care During the COVID-19 Pandemic in the United States and Switzerland: Balancing Protection and Social Isolation
While frontline healthcare workers in intensive care units played a central role during the COVID-19 pandemic, the staff of long-term residential care who cared for older adults were largely forgotten. This is...
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Policies and Politics: An Analysis of Public Policies Aimed at the Reorganisation of Healthcare Delivery During the COVID-19 Pandemic
Policies and politics have been pivotal in the public health response to the COVID-19 pandemic, often dictating the trajectory of the pandemic through the introduction of restrictive methods to curb the spread...
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Somatic mutation landscapes at single-molecule resolution
Somatic mutations drive the development of cancer and may contribute to ageing and other diseases1,2. Despite their importance, the difficulty of detecting mutations that are only present in single cells or small...
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Article
Stokes waves revisited: Exact solutions in the asymptotic limit
The Stokes perturbative solution of the nonlinear (boundary value dependent) surface gravity wave problem is known to provide results of reasonable accuracy to engineers in estimating the phase speed and ampli...
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After the Asylum in Canada: Surviving Deinstitutionalisation and Revising History
Psychiatric deinstitutionalisation began in in earnest during the 1960s and continues today. The downsizing and closure of custodial mental hospitals did not occur uniformly across the country, and regional ...
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Open AccessLinking public health agencies and hospitals for improved emergency preparedness: North Carolina's public health epidemiologist program
In 2003, 11 public health epidemiologists were placed in North Carolina's largest hospitals to enhance communication between public health agencies and healthcare systems for improved emergency preparedness. W...
