-
Article
Open AccessClustering of HR + /HER2− breast cancer in an Asian cohort is driven by immune phenotypes
Breast cancer exhibits significant heterogeneity, manifesting in various subtypes that are critical in guiding treatment decisions. This study aimed to investigate the existence of distinct subtypes of breast ...
-
Article
Breaking the Barrier: A Study on Multi-drug Resistance in Breast Abscess at an Academic Malaysian Hospital
In recent years, the increase in antibiotics usage locally has led to a worrying emergence of multi-drug resistant organisms (MDRO), with the Malaysian prevalence rate of methicillin-resistant Staphylococcus aure...
-
Article
Exploring the health information-seeking practices of breast cancer patients in a middle-income country with a diverse ethnic population: a cross-sectional investigation
Seeking health information is an important step for cancer patients to understand their condition and facilitate treatment. It also helps them deal with the unknown and aid in recovery. Therefore, it is vital ...
-
Article
Open AccessFactors associated with alteration of nipple or skin sensation and impact of duration of time following nipple-sparing mastectomy (NSM): an analysis of 460 cases with comparison of conventional versus endoscopic- or robotic-assisted NSM
The current study aims to evaluate the nipple and skin sensation following nipple-sparing mastectomy (NSM) and identify patient-, surgical-, or treatment-related factors affecting nipple or skin sensation in t...
-
Article
Comparison of Clinical Outcomes Between Low- and High-Risk Groups of Early Breast Cancer Patients Treated with Intraoperative Radiotherapy in Addition to External Beam Radiation: A Multi-Centre Prospective Study
There is a paucity of data on the use of intraoperative radiotherapy (IORT) with low-energy X-rays in Malaysian women with early breast cancer. The aim of this study is to evaluate the clinical, cosmetic, and ...
-
Article
Open AccessPsychological distress among elderly surgical patients who had their surgery postponed during the COVID-19 pandemic
Many institutions withheld elective lists and triaged surgeries during the peak of coronavirus disease 2019 (COVID-19) pandemic. As a result, older surgical patients have had to wait for rescheduled dates in a...
-
Article
Psychological distress among cancer survivors during implementation of a nationwide Movement Control Order over the COVID-19 pandemic
This study aimed to investigate the psychological distress and its associated factors among cancer survivors in Malaysia during the COVID-19 pandemic.
-
Article
Significant factors influencing inadvertent hypothermia in pediatric anesthesia
Thermal imbalances are very common during surgery. Hypothermia exposes the patient to post-operative shivering, cardiac dysfunction, coagulopathy, bleeding, wound infection, delayed anesthesia recovery, prolon...
-
Article
Impact of Time Since Last Childbirth on Survival of Women with Premenopausal and Postmenopausal Breast Cancers
Reproductive factors are associated with risk of breast cancer, but the association with breast cancer survival is less well known. Previous studies have reported conflicting results on the association between...
-
Article
Missed Opportunities for Loco-Regional Treatment of Elderly Women with Breast Cancer
Factors associated with surgery, adjuvant radiotherapy, and chemotherapy and whether there were missed opportunities for treatment in elderly patients were determined in an Asian setting.
-
Article
Open AccessAnxiety, depression, perceived social support and quality of life in Malaysian breast cancer patients: a 1-year prospective study
Depression and anxiety are common psychiatric morbidity among breast cancer patient. There is a lack of study examining the correlation between depression, anxiety and quality of life (QoL) with perceived soci...
-
Article
Open AccessTrends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting
Up to 25% of breast cancer patients in Asia present with de novo metastatic disease. We examined the survival trends of Asian patients with metastatic breast cancer over fifteen years. The impact of changes in pa...
-
Article
Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells
Metformin, an AMPK activator, has been reported to improve pathological response to chemotherapy in diabetic breast cancer patients. To date, its mechanism of action in cancer, especially in cancer stem cells ...
-
Article
Open AccessOpportunistic mammography screening provides effective detection rates in a limited resource healthcare system
Breast cancer is the leading cause of cancer deaths in women world-wide. In low and middle income countries, where there are no population-based mammographic screening programmes, late presentation is common, ...
