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Article
The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC
Immunotherapy revolutionized treatment options in cancer, yet the mechanisms underlying resistance in many patients remain poorly understood. Cellular proteasomes have been implicated in modulating antitumor i...
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Article
Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors
Post-translational modification (PTM) of antigens provides an additional source of specificities targeted by immune responses to tumors or pathogens, but identifying antigen PTMs and assessing their role in sh...
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Article
Open AccessThe survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5
B cells have essential functions in multiple sclerosis and in its mouse model, experimental autoimmune encephalomyelitis, both as drivers and suppressors of the disease. The suppressive effects are driven by a...
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Article
Open AccessGolgi organization is regulated by proteasomal degradation
The Golgi is a dynamic organelle whose correct assembly is crucial for cellular homeostasis. Perturbations in Golgi structure are associated with numerous disorders from neurodegeneration to cancer. However, w...
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Article
Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides
Cleavage products of the proteasome are profiled by mass spectrometry.
