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Article
Autonomous rhythmic activity in glioma networks drives brain tumour growth
Diffuse gliomas, particularly glioblastomas, are incurable brain tumours1. They are characterized by networks of interconnected brain tumour cells that communicate via Ca2+ transients2–6. However, the networks’ a...
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Article
Open AccessTumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
Both the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have been associated with progression and resistance to therapies in glioblastoma, but their specific...
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Article
Emerging intersections between neuroscience and glioma biology
The establishment of neuronal and glial networks in the brain depends on the activities of neural progenitors, which are influenced by cell-intrinsic mechanisms, interactions with the local microenvironment an...
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Article
Brain tumour cells interconnect to a functional and resistant network
Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized by diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend ultra-long membrane protrus...
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Article
A vaccine targeting mutant IDH1 induces antitumour immunity
The mutant IDH1 protein, which is expressed in a large fraction of human gliomas, is shown to be immunogenic; mutant-specific immune responses can be detected in patients with IDH1 mutated gliomas and generate...
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Article
Towards optimizing the sequence of bevacizumab and nitrosoureas in recurrent malignant glioma
Studies on the monoclonal VEGF-A antibody bevacizumab gave raise to questions regarding the lack of an overall survival benefit, the optimal timing in the disease course and potential combination and salvage ...
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Article
Insights into cell-to-cell and cell-to-blood-vessel communications in the brain: in vivo multiphoton microscopy
A complex and reciprocal communication of cells with each other and with relevant parts of the tissue stroma governs many biological processes in both health and disease. However, in the past, the study of the...
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Article
Open AccessDoes age matter? - A MRI study on peritumoral edema in newly diagnosed primary glioblastoma
Peritumoral edema is a characteristic feature of malignant glioma related to the extent of neovascularisation and to vascular endothelial growth factor (VEGF) expression.
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Chapter and Conference Paper
Finding Knees in Multi-objective Optimization
Many real-world optimization problems have several, usually conflicting objectives. Evolutionary multi-objective optimization usually solves this predicament by searching for the whole Pareto-optimal front of ...
