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Open AccessPixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy
High-speed wide-field fluorescence microscopy has the potential to capture biological processes with exceptional spatiotemporal resolution. However, conventional cameras suffer from low signal-to-noise ratio a...
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Article
Open AccessGeneration of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method
Cancer immunotherapy with autologous chimeric antigen receptor (CAR) T cells faces challenges in manufacturing and patient selection that could be avoided by using ‘off-the-shelf’ products, such as allogeneic ...
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Article
Behavioral Indicators of Deception and Associated Mental States: Scientific Myths and Realities
We suggest a reconsideration of broad and swee** claims that research has demonstrated that nonverbal behavior (NVB) are not indicators of deception. We reexamine several methodological characteristics of a ...
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Article
Open AccessStudy protocol for a randomised controlled trial to investigate the effectiveness of thoracic epidural and paravertebral blockade in reducing chronic post-thoracotomy pain: 2 (TOPIC 2)
Thoracotomy is considered one of the most painful surgical procedures and can cause debilitating chronic post-surgical pain lasting months or years postoperatively. Aggressive management of acute pain resultin...
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Chapter
Stem Cell-Derived Cell Therapy for Cancer
The advent of genetic engineering strategies has transformed the landscape of cancer immunotherapy, leading to the development and adoption of CAR-T cell therapy. However, the current autologous CAR-T cell pla...
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Article
Effects of multiple discrete emotions on risk-taking propensity
Previous studies have examined the effects of discrete emotions on risk taking. One unstudied question in this literature involves comparisons of multiple discrete emotions, not limited to two (e.g., anger vs....
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High-Fidelity Experiments, Situationism, and the Measurement of Virtue
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The influence of coastal geomorphology and human activity on plastic debris distribution on a micro-tidal recreational beach on the north coast of Trinidad
Coastal plastic debris is a major problem affecting both sandy beaches and nearshore environments. Over several decades, plastic debris has become a global threat to the natural environment due in part to sing...
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Article
Open AccessMelatonin for pre-medication in children: a systematic review
Melatonin’s effectiveness as an anxiolytic medication has been confirmed in adults; however, its efficacy in a paediatric population is unclear. A number of small studies have assessed its use in children as a...
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Article
Open AccessRetinoblastoma from human stem cell-derived retinal organoids
Retinoblastoma is a childhood cancer of the develo** retina that initiates with biallelic inactivation of the RB1 gene. Children with germline mutations in RB1 have a high likelihood of develo** retinoblastom...
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Article
Spin-induced linear polarization of photoluminescence in antiferromagnetic van der Waals crystals
Antiferromagnets are promising components for spintronics due to their terahertz resonance, multilevel states and absence of stray fields. However, the zero net magnetic moment of antiferromagnets makes the de...
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Signatures of moiré trions in WSe2/MoSe2 heterobilayers
Moiré superlattices formed by van der Waals materials can support a wide range of electronic phases, including Mott insulators1–4, superconductors5–10 and generalized Wigner crystals2. When excitons are confined ...
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Article
Government market power and public goods provision in a federation
In standard models of fiscal federalism, tax competition among subnational jurisdictions depresses government expenditures. Centralization therefore increases government spending, assuming that both local and ...
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Chapter
Things About a Highly Strung Evangelist, 1818–1838
About the family farm, boarding school, and chapel, the young Richard Congreve encountered conflicting social outlooks. He faced the radical thinking of farmhands, the severe conservativism of his father, and ...
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A ‘Man of Fiery Temperament’, 1845–1852
Richard Congreve experienced great inner turmoil during his tenure at Rugby School. On discovering that for various reasons he was persona non grata, he immersed himself in the works of Thomas Carlyle, G. H. Lewe...
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Comtist ‘Vicar’ and ‘Accuser of the Nation’, 1857–1866
By the 1860s, Richard Congreve had metamorphosed into a polymath of multifarious vocations. He published anti-imperialist tracts, began studying medicine, and translated the religious utterances of Auguste Com...
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‘Pope’ of Back-Parlour ‘Ambiguities and Illusions’, 1877–1899
In 1877, Richard Congreve entered a secret plot to undermine the leadership of the international Positivist movement. After one of his co-conspirators exposed his ill-fated ambitions, Congreve severed all conn...
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Prelude: ‘Who Is RICHARD CONGREVE?’ It Will Be Asked
‘“Who is RICHARD CONGREVE?” It will be asked.’ was the first widely distributed review of the philosopher’s anti-imperialist ideas. The date was 16 January 1858, and The Times’ reviewers presented Congreve as at ...
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Chapter
Once Timorous, Now a ‘Very Dangerous’ Infidel, 1838–1845
The late 1830s were years of severe sadness, new friendships, and intensive study for Richard Congreve. Within a decade’s time, people considered this Anglican minister a ‘very dangerous’ man. This chapter arg...
