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Article
Releasing uncurated datasets is essential for reproducible phylogenomics
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Article
Open AccessAn efficient single-cell transcriptomics workflow for microbial eukaryotes benchmarked on Giardia intestinalis cells
Most diversity in the eukaryotic tree of life is represented by microbial eukaryotes, which is a polyphyletic group also referred to as protists. Among the protists, currently sequenced genomes and transcripto...
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Article
Open AccessCold climate adaptation is a plausible cause for evolution of multicellular sporulation in Dictyostelia
Unicellular protozoa that encyst individually upon starvation evolved at least eight times into organisms that instead form multicellular fruiting bodies with spores. The Dictyostelia are the largest and most ...
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Article
A genetic toolbox for marine protists
A resource of detailed DNA delivery and expression protocols for marine protists will enable new studies to understand the fundamental and ancestral features of eukaryotic cells.
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Article
Open AccessIntegrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma
Aberrant activation of Axl is implicated in the progression of hepatocellular carcinoma (HCC). We explored the biologic significance and preclinical efficacy of Axl inhibition as a therapeutic strategy in sora...
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Reference Work Entry In depth
AXL
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Reference Work Entry In depth
Apusomonadida
Apusomonadida is a small group of free-living heterotrophic flagellates. Apusomonads are small (~5–20 μm long) gliding aerobes with two flagella. The dorsal cell membrane is underlain by a pellicle, which also...
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Living Reference Work Entry In depth
Protosteloid Amoebae (Protosteliida, Protosporangiida, Cavosteliida, Schizoplasmodiida, Fractoviteliida, and Sporocarpic Members of Vannellida, Centramoebida, and Pellitida)
Protosteloid amoebozoans, formerly called protostelids, are a non-monophyletic assemblage of Amoebozoa where, at one point in their development, an amoeba rounds up on the surface of a substrate and develops i...
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Reference Work Entry In depth
Heterolobosea
Heterolobosea is a group of ~150 described species of heterotrophs, almost all free living. Many are “amoeboflagellates” with a three-phase asexual life cycle, centered on trophic amoebae that can reversibly t...
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Reference Work Entry In depth
Protosteloid Amoebae (Protosteliida, Protosporangiida, Cavosteliida, Schizoplasmodiida, Fractoviteliida, and Sporocarpic Members of Vannellida, Centramoebida, and Pellitida)
Protosteloid amoebozoans, formerly called protostelids, are a non-monophyletic assemblage of Amoebozoa where, at one point in their development, an amoeba rounds up on the surface of a substrate and develops i...
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Article
Open AccessExpansion of the molecular and morphological diversity of Acanthamoebidae (Centramoebida, Amoebozoa) and identification of a novel life cycle type within the group
Acanthamoebidae is a “family” level amoebozoan group composed of the genera Acanthamoeba, Protacanthamoeba, and very recently Luapeleamoeba. This clade of amoebozoans has received considerable attention from the ...
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Article
Environmental Breviatea harbour mutualistic Arcobacter epibionts
The cultivation of Lenisia limosa, a newly discovered breviate protist, symbiotically colonized by relatives of the animal-associated bacterium Arcobacter.
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Living Reference Work Entry In depth
Heterolobosea
Heterolobosea is a group of ~150 described species of heterotrophs, almost all free living. Many are “amoeboflagellates” with a three-phase asexual life cycle, centered on trophic amoebae that can reversibly t...
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Living Reference Work Entry In depth
AXL
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Living Reference Work Entry In depth
Apusomonadida
Apusomonadida is a small group of free-living heterotrophic flagellates. Apusomonads are small (~5–20 μm long) gliding aerobes with two flagella. The dorsal cell membrane is underlain by a pellicle, which also...
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Chapter
Timing the Origins of Multicellular Eukaryotes Through Phylogenomics and Relaxed Molecular Clock Analyses
Multicellularity has evolved many times during eukaryote evolution. Deciphering the evolutionary transitions to multicellularity requires a robust deep phylogeny of eukaryotes to clarify the relationships amon...
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Article
Open AccessNucleomorph and plastid genome sequences of the chlorarachniophyte Lotharella oceanica: convergent reductive evolution and frequent recombination in nucleomorph-bearing algae
Nucleomorphs are residual nuclei derived from eukaryotic endosymbionts in chlorarachniophyte and cryptophyte algae. The endosymbionts that gave rise to nucleomorphs and plastids in these two algal groups were ...
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Article
Open AccessThe Capsaspora genome reveals a complex unicellular prehistory of animals
To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflag...
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Article
Open AccessParallel re-modeling of EF-1α function: divergent EF-1α genes co-occur with EFL genes in diverse distantly related eukaryotes
Elongation factor-1α (EF-1α) and elongation factor-like (EFL) proteins are functionally homologous to one another, and are core components of the eukaryotic translation machinery. The patchy distribution of th...
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Chapter
The Non-dictyostelid Sorocarpic Amoebae
The social life cycle made famous through research on the dictyostelids is not an evolutionary innovation that is solely unique to the dictyostelids. Since 1873, other protistans with similar life styles have ...
