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Article
Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies
Cellular senescence is a state of permanent growth arrest that plays an important role in wound healing, tissue fibrosis, and tumor suppression. Despite senescent cells’ (SnCs) pathological role and therapeuti...
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Article
Spectral cytometry on highly autofluorescent samples
Engineered materials induce immune responses when implanted in vivo. The autofluorescence spectra of responding cells can be captured by spectral cytometry. We discuss the necessary considerations when perform...
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Article
Open AccessAn immunologically active, adipose-derived extracellular matrix biomaterial for soft tissue reconstruction: concept to clinical trial
Soft tissue reconstruction remains an intractable clinical challenge as current surgical options and synthetic implants may produce inadequate outcomes. Soft tissue deficits may be surgically reconstructed usi...
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Article
Erratum to: Intra-articular Injection of Urinary Bladder Matrix Reduces Osteoarthritis Development
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Article
Intra-articular Injection of Urinary Bladder Matrix Reduces Osteoarthritis Development
Micronized porcine urinary bladder matrix (UBM) is an extracellular matrix biomaterial that has immunomodulatory and pro-regenerative properties. The objective of this study was to assess the ability of UBM to...
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Article
Design, clinical translation and immunological response of biomaterials in regenerative medicine
The field of regenerative medicine aims to replace tissues lost as a consequence of disease, trauma or congenital abnormalities. Biomaterials serve as scaffolds for regenerative medicine to deliver cells, prov...
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Article
Tissue matrix arrays for high-throughput screening and systems analysis of cell function
High-throughput tissue arrays allow for evaluation of in vitro cellular responses and correlation to matrix composition.
