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Open AccessToward a Unified Account of Advanced Concentrative Absorption Meditation: A Systematic Definition and Classification of Jhāna
The jhānas are series of advanced concentrative absorption meditative (ACAM) states brought about by meditation. While previously cultivated mostly in monastic settings, a series of modern meditation manuals b...
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Open AccessNeurophenomenological Investigation of Mindfulness Meditation “Cessation” Experiences Using EEG Network Analysis in an Intensively Sampled Adept Meditator
Mindfulness meditation is a contemplative practice that is informed by Buddhism. It has been proven effective for improving mental and physical health in clinical and non-clinical contexts. To date, mainstream...
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Open AccessAltered States of Consciousness are Prevalent and Insufficiently Supported Clinically: A Population Survey
Adoption of potentially consciousness-altering practices may be leading to a rise in emergent phenomena (EP): sudden unusual mental or somatic experiences often interpreted as spiritual, mystical, energetic, o...
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Article
Open AccessDevelopment of a digital intervention for psychedelic preparation (DIPP)
Psychedelic substances induce profound alterations in consciousness. Careful preparation is therefore essential to limit adverse reactions, enhance therapeutic benefits, and maintain user safety. This paper de...
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Article
Open AccessNeuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo
Major depressive disorder (MDD) is a heterogeneous clinical syndrome with widespread subtle neuroanatomical correlates. Our objective was to identify the neuroanatomical dimensions that characterize MDD and pr...
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Open AccessMulti-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures
Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing alg...
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Article
Open AccessSubject-specific whole-brain parcellations of nodes and boundaries are modulated differently under 10 Hz rTMS
Repetitive transcranial magnetic stimulation (rTMS) has gained considerable importance in the treatment of neuropsychiatric disorders, including major depression. However, it is not yet understood how rTMS alt...
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Open AccessFunctional connectivity signatures of major depressive disorder: machine learning analysis of two multicenter neuroimaging studies
The promise of machine learning has fueled the hope for develo** diagnostic tools for psychiatry. Initial studies showed high accuracy for the identification of major depressive disorder (MDD) with resting-s...
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Open AccessUniting Contemplative Theory and Scientific Investigation: Toward a Comprehensive Model of the Mind
Research into meditation-related emergent phenomenology is advancing, yet progress is hampered by significant incongruities between meditator self-reports and objective measurements (e.g., of brain states). We...
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Open AccessA Framework for the Empirical Investigation of Mindfulness Meditative Development
Millions of people globally have learned mindfulness meditation with the goal of improving health and well-being outcomes in both clinical and non-clinical contexts. An estimated half of these practitioners fo...
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Open AccessAI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale
Efforts to develop neuroimaging-based biomarkers in major depressive disorder (MDD), at the individual level, have been limited to date. As diagnostic criteria are currently symptom-based, MDD is conceptualize...
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Open AccessCorrection: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders
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Open AccessAltered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium
Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be measured by assessing functional connectivity (FC) at resting-state functional MRI, that may help identifying neural mark...
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Open AccessBrain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this ...
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Open AccessBrain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders
Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n = 6420) and genetic data ...
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Article
Open AccessThalamic and prefrontal GABA concentrations but not GABAA receptor densities are altered in high-functioning adults with autism spectrum disorder
The gamma aminobutyric acid (GABA) neurotransmission system has been implicated in autism spectrum disorder (ASD). Molecular neuroimaging studies incorporating simultaneous acquisitions of GABA concentrations ...
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Open AccessFunctional network alterations differently associated with suicidal ideas and acts in depressed patients: an indirect support to the transition model
The transition from suicidal ideas to a suicide act is an important topic of research for the identification of those patients at risk of acting out. We investigated here whether specific brain activity and co...
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Open AccessBrain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group
It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated...
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Open AccessWhite matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistic...
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Article
Open AccessENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing
A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain proce...
