4 Result(s)
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Article
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers
Adult liver malignancies, including intrahepatic cholangiocarcinoma and hepatocellular carcinoma, are the second leading cause of cancer-related deaths worldwide. Most individuals are treated with either combi...
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Article
Open AccessThe trans-generational impact of population density signals on host-parasite interactions
The density of a host population is a key parameter underlying disease transmission, but it also has implications for the expression of disease through its effect on host physiology. In response to higher dens...
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Article
Open AccessAn SNP-based second-generation genetic map of Daphnia magna and its application to QTL analysis of phenotypic traits
Although Daphnia is increasingly recognized as a model for ecological genomics and biomedical research, there is, as of yet, no high-resolution genetic map for the genus. Such a map would provide an important too...
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Article
Open AccessThe genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial. Here, we focus on ...
