5 Result(s)
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Article
Surrounded by ligands: the reactivity of cisplatin in cell culture medium
The reactivity of platinum-containing drugs such as cisplatin, carboplatin, and oxaliplatin is essential for its mechanism of action as an anticancer agent. This inherent reactivity means that molecules in too...
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Protocol
In Vivo Bioluminescent Imaging of ATP-Binding Cassette Transporter-Mediated Efflux at the Blood–Brain Barrier
We provide a detailed protocol for imaging ATP-binding cassette subfamily G member 2 (ABCG2) function at the blood–brain barrier (BBB) of transgenic mice. d-Luciferin is specifically transported by ABCG2 found on...
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Chapter
The ABCG2 Multidrug Transporter
ABCG2 is an ATP-binding cassette (ABC) half-transporter localized to the cell membrane and important in normal physiology, in normal tissue protection including in the maternal-fetal barrier and the blood brai...
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Article
Evaluation of fluorophore-tethered platinum complexes to monitor the fate of cisplatin analogs
The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and as a consequence have been extensively studied in the laboratory setting, sometimes by generating fluorophore-ta...
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Article
The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells
The cellular distribution of platinum in A2780 ovarian cancer cells treated with cisplatin and platinum(IV) complexes with a range of reduction potentials has been examined using elemental analysis (synchrotro...
