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  1. Article

    Open Access

    Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus

    PIK3CA encoding the phosphoinositide 3-kinase (PI3K) p110α catalytic subunit is frequently mutated in cancer, with mutations occurring widely throughout the primary sequence. The full set of mechanisms underlying...

    Meredith L. Jenkins, Harish Ranga-Prasad, Matthew A. H. Parson… in Nature Communications (2023)

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  2. Article

    Open Access

    Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane

    Calcineurin, the conserved protein phosphatase and target of immunosuppressants, is a critical mediator of Ca2+ signaling. Here, to discover calcineurin-regulated processes we examined an understudied isoform, CN...

    Idil Ulengin-Talkish, Matthew A. H. Parson, Meredith L. Jenkins… in Nature Communications (2021)

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