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Article
Open AccessTau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases
Tau neurofibrillary tangles are a hallmark of Alzheimer’s disease neuropathological change. However, it remains largely unclear how distinctive Alzheimer’s disease tau seeds (i.e. 3R/4R) correlate with histolo...
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Article
Open AccessCryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains
Little is known about the structural basis of prion strains. Here we provide a high (3.0 Å) resolution cryo-electron microscopy-based structure of infectious brain-derived fibrils of the mouse anchorless RML s...
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Article
Characterizing user behavior in journey planning
Journey planners support users in the organization of their trips, by presenting them results with multimodal solutions. While the benefits for the users are straightforward, other stakeholders (such as transp...
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Article
Open AccessPublisher Correction: Early preclinical detection of prions in the skin of prion-infected animals
The original version of this Article contained errors in the author affiliations. Affiliation 2 incorrectly read ‘Department of Neurology, The First Hospital of Jilin University, Changchun 130021 Jilin Provinc...
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Article
Open AccessEarly preclinical detection of prions in the skin of prion-infected animals
A definitive pre-mortem diagnosis of prion disease depends on brain biopsy for prion detection currently and no validated alternative preclinical diagnostic tests have been reported to date. To determine the f...
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Article
Guest Editorial: Behavioral-Data Mining in Information Systems and the Big Data Era
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Article
Behavioral data mining to produce novel and serendipitous friend recommendations in a social bookmarking system
In the last few years, social media systems have experienced a fast growth. The amount of content shared in these systems increases fast, leading users to face the well known “interaction overload” problem, i....
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Protocol
Detection and Diagnosis of Prion Diseases Using RT-QuIC: An Update
Until recently, it has been difficult to detect all infectious levels of prions and diagnose prion diseases in living humans and other animals. Real-time quaking-induced conversion (RT-QuIC), an ultrasensitive...
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Protocol
RT-QuIC Assays for Prion Disease Detection and Diagnostics
In co** with prion diseases, it is important to have tests that are practical enough for routine applications in medicine, agriculture, wildlife biology, and research, yet sensitive enough to detect minimal ...
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Chapter and Conference Paper
Friend Recommendation in a Social Bookmarking System: Design and Architecture Guidelines
Social media systems allow users to share resources with the people connected to them. In order to handle the exponential growth of the content in these systems and of the amount of users that populate them, r...
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Chapter and Conference Paper
Using Behavioral Data Mining to Produce Friend Recommendations in a Social Bookmarking System
Social recommender systems have been developed to filter the large amounts of data generated by social media systems. A type of social media, known as social bookmarking system, allows the users to tag bookmarks ...
