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Article
Open AccessFrailty is a stronger predictor of death in younger intensive care patients than in older patients: a prospective observational study
While frailty is a known predictor of adverse outcomes in older patients, its effect in younger populations is unknown. This prospective observational study was conducted in a tertiary-level mixed ICU to asses...
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Article
Open AccessSerotonin and dopamine transporter availability in social anxiety disorder after combined treatment with escitalopram and cognitive-behavioral therapy
Selective serotonin reuptake inhibitors (SSRIs) and internet-based cognitive behavioral therapy (ICBT) are recommended treatments of social anxiety disorder (SAD), and often combined, but their effects on mono...
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Article
Open AccessImpact of persistent peripheral neuropathy on health-related quality of life among early-stage breast cancer survivors: a population-based cross-sectional study
We explored the impact of persistent sensory and motor taxane-induced peripheral neuropathy (TIPN) symptoms on health-related quality of life (HRQL) among early-stage breast cancer survivors (ESBCS).
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Article
Open AccessDopamine and fear memory formation in the human amygdala
Learning which environmental cues that predict danger is crucial for survival and accomplished through Pavlovian fear conditioning. In humans and rodents alike, fear conditioning is amygdala-dependent and rest...
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Article
Open AccessExpectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder: a randomized clinical trial
It has been extensively debated whether selective serotonin reuptake inhibitors (SSRIs) are more efficacious than placebo in affective disorders, and it is not fully understood how SSRIs exert their beneficial...
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Article
Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: a multitracer positron emission tomography study
Serotonin and dopamine are putatively involved in the etiology and treatment of anxiety disorders, but positron emission tomography (PET) studies probing the two neurotransmitters in the same individuals are l...
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PET and SPECT Studies in Anxiety Disorders
Neuroimaging studies using PET and SPECT to evaluate neurofunctional differences between patients with anxiety- and stress-related disorders and healthy controls were reviewed. At rest, patients with social an...
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Article
Open AccessClinical characteristics and blood/serum bound prognostic biomarkers in advanced pancreatic cancer treated with gemcitabine and nab-paclitaxel
In recent years treatment options for advanced pancreatic cancer have markedly improved, and a combination regimen of gemcitabine and nab-paclitaxel is now considered standard of care in Sweden and elsewhere. ...
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Article
Open AccessDecrease in amygdala activity during repeated exposure to spider images predicts avoidance behavior in spider fearful individuals
Spider phobia is characterized by exaggerated fear of situations where spiders could be present, resulting in avoidance of such situations and compromised quality of life. An important component in psychologic...
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Article
Open AccessDelay of appropriate antibiotic treatment is associated with high mortality in patients with community-onset sepsis in a Swedish setting
Early appropriate antimicrobial therapy is crucial in patients with sepsis and septic shock. Studies often focus on time to first dose of appropriate antibiotics, but subsequent dosing is equally important. Ou...
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Article
Open AccessFemale risk-adjusted survival advantage after injuries caused by falls, traffic or assault: a nationwide 11-year study
A female survival advantage after injury has been observed, and animal models of trauma have suggested either hormonal or genetic mechanisms as component causes. Our aim was to compare age and risk-adjusted se...
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Article
Open AccessPolymorphisms in CARD8 and NLRP3 are associated with extrapulmonary TB and poor clinical outcome in active TB in Ethiopia
Innate immunity is a first line defense against Mycobacterium tuberculosis infection where inflammasome activation and secretion of the pro-inflammatory cytokine IL-1beta, plays a major role. Thus, genetic polymo...
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Article
Open AccessCeliac disease biomarkers identified by transcriptome analysis of small intestinal biopsies
Establishing a celiac disease (CD) diagnosis can be difficult, such as when CD-specific antibody levels are just above cutoff or when small intestinal biopsies show low-grade injuries. To investigate the biolo...
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Article
Open AccessDeterminants of mortality after hip fracture surgery in Sweden: a registry-based retrospective cohort study
Surgery for hip fractures is associated with high mortality and morbidity. The causes of poor outcome are not fully understood and may be related to other factors than the surgery itself. The relative contribu...
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Open AccessAssociation between amygdala neurokinin-1 receptor availability and anxiety-related personality traits
Animal studies indicate that substance P (SP) and its preferred neurokinin-1 (NK1) receptor modulate stress and anxiety-related behavior. Alterations in the SP-NK1 system have also been observed in human anxie...
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Article
Open AccessAre there any differences in the provided burn care between men and women? A retrospective study
Disparity between medical treatment for men and women has been recorded worldwide. However, it is difficult to find out if the disparities in both the use of resources and outcome depend entirely on sex-relate...
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Article
Open AccessDecreased risk adjusted 30-day mortality for hospital admitted injuries: a multi-centre longitudinal study
The interpretation of changes in injury-related mortality over time requires an understanding of changes in the incidence of the various types of injury, and adjustment for their severity. Our aim was to inves...
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Article
Hormonal Cycle and Contraceptive Effects on Amygdala and Salience Resting-State Networks in Women with Previous Affective Side Effects on the Pill
The mechanisms linking ovarian hormones to negative affect are poorly characterized, but important clues may come from the examination of the brain’s intrinsic organization. Here, we studied the effects of bot...
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Article
Open AccessEarly feeding and risk of Juvenile idiopathic arthritis: a case control study in a prospective birth cohort
Juvenile idiopathic arthritis (JIA) is considered to be an autoimmune disease, but the etiology is unknown. We decided to study the influence of early nutrition on later development of JIA.
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Article
Open AccessRegression models for analyzing radiological visual grading studies – an empirical comparison
For optimizing and evaluating image quality in medical imaging, one can use visual grading experiments, where observers rate some aspect of image quality on an ordinal scale. To analyze the grading data, sever...
