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    Article

    Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

    Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-1...

    Noella Lopes, Claire McIntyre, Stefania Martin, Mathilde Raverdeau… in Nature Immunology (2021)

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    Article

    Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

    Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms include overproduction of hormones, adipokines, and insulin. Cytotoxic immune cells, including natural killer (NK) cells...

    Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus… in Nature Immunology (2018)