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  1. Article

    Open Access

    Endothelin receptor antagonist and airway dysfunction in pulmonary arterial hypertension

    In idiopathic pulmonary arterial hypertension (IPAH), peripheral airway obstruction is frequent. This is partially attributed to the mediator dysbalance, particularly an excess of endothelin-1 (ET-1), to incre...

    Annette S Droste, David Rohde, Mirko Voelkers, Arthur Filusch… in Respiratory Research (2009)

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    Article

    Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1

    To elucidate the ionic mechanism of endothelin-1 (ET-1)-induced focal ventricular tachyarrhythmias, the regulation of IK1 and its main molecular correlates, Kir2.1, Kir2.2 and Kir2.3 channels, by ET-1 was investi...

    Claudia Kiesecker, Edgar Zitron, Daniel Scherer… in Journal of Molecular Medicine (2006)

  3. No Access

    Article

    Value of high spatial and high temporal resolution magnetic resonance angiography for differentiation between idiopathic and thromboembolic pulmonary hypertension: initial results

    Differentiation between different forms of pulmonary hypertension (PH) is essential for correct disease management. The goal of this study was to elucidate the clinical impact of high spatial resolution MR ang...

    Sebastian Ley, Christian Fink, Julia Zaporozhan, Mathias M. Borst… in European Radiology (2005)

  4. Article

    Open Access

    Are ICD-10 codes appropriate for performance assessment in asthma and COPD in general practice? Results of a cross sectional observational study

    The increasing prevalence and impact of obstructive lung diseases and new insights, reflected in clinical guidelines, have led to concerns about the diagnosis and therapy of asthma and COPD in primary care. In...

    Antonius Schneider, Lutz Gantner, Inko Maag… in BMC Health Services Research (2005)

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  5. No Access

    Article

    Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy

    Protein kinase C (PKC) is a family of at least 11 isozymes and known to play a crucial role in myocardial growth. The present study was performed to investigate whether PKC-isozymes are differentially regulate...

    Martin U. Braun, Paul LaRosée, Gregor Simonis… in Molecular and Cellular Biochemistry (2004)

  6. No Access

    Article

    Assessment of pulmonary hypertension by CT and MR imaging

    In the recent World Health Organization (WHO) classification the group of pulmonary arterial hypertension (PH) comprises the classic primary pulmonary hypertension and several conditions with definite or very ...

    Sebastian Ley, Karl-Friedrich Kreitner, Christian Fink… in European Radiology (2004)

  7. No Access

    Article

    Inefficient ventilation and reduced respiratory muscle capacity in congestive heart failure

    The extent and time-course of changes in lung volumes, ventilatory efficiency at rest and during exercise, and respiratory muscle function and their influence on exercise limitation in congestive heart failur...

    F. Joachim Meyer, Christian Zugck, Markus Haass… in Basic Research in Cardiology (2000)

  8. No Access

    Article

    Blockade of A1 adenosine receptors prevents the ischaemia-induced sensitisation of adenylyl cyclase: evidence for a protein kinase C-mediated pathway

    Objective: Acute myocardial ischaemia leads to a transient sensitisation of adenylyl cyclase which may contribute to the occurrence of malignant arrhythmias and the propagation of myocardial necrosis. It is prev...

    Mathias M. Borst, Gregor Simonis, Jochen Röthele… in Basic Research in Cardiology (1999)