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Article
Open AccessMultiomics analysis of cultured mouse periodontal ligament cell-derived extracellular matrix
A comprehensive understanding of the extracellular matrix (ECM) is essential for develo** biomimetic ECM scaffolds for tissue regeneration. As the periodontal ligament cell (PDLC)-derived ECM has shown poten...
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Article
Open AccessDNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle
Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and translational efficiency control tissue-dominant protein produc...
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Article
Open AccessRPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function
Although several ribosomal protein paralogs are expressed in a tissue-specific manner, how these proteins affect translation and why they are required only in certain tissues have remained unclear. Here we sho...
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Article
Open AccessHSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis
Transcriptional regulation by RNA polymerase II is associated with changes in chromatin structure. Activated and promoter-bound heat shock transcription factor 1 (HSF1) recruits transcriptional co-activators, ...
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Article
Open AccessA phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the ...
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Article
Open AccessCell cycle–dependent localization of the proteasome to chromatin
An integrative understanding of nuclear events including transcription in normal and cancer cells requires comprehensive and quantitative measurement of protein dynamics that underlie such events. However, the...
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Article
Open AccessA shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific metabolic changes remains unclear. Here we show, using the comprehensive measurement of metabolic enzymes by large-scale tar...
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Article
Open AccessThe role of Mediator and Little Elongation Complex in transcription termination
Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes. Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment of Super Elongation Complex (S...
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Article
Open AccessAkt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
Th2 cells produce Th2 cytokines such as IL-4, IL-5 and IL-13, but repress Th1 cytokine IFNγ. Recent studies have revealed various distinct memory-type Th2 cell subsets, one of which produces a substantial amou...
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A Study of a Development of Internal Exposure Management Tool Suited for Japanese Diet Behavior
After the Fukushima Nuclear Power Plant accident, one of the main issues at stake was the potential intake of contaminated foodstuff by residents of the affected areas. In this context, the importance of the m...
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Article
Open AccessTissue-specific expression of histone H3 variants diversified after species separation
The selective incorporation of appropriate histone variants into chromatin is critical for the regulation of genome function. Although many histone variants have been identified, a complete list has not been c...
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Article
Overexpression of Ephrin A2 receptors in cancer stromal cells is a prognostic factor for the relapse of gastric cancer
Microenvironments control cancer growth and progression. We explored the prognostic impact of stromal reaction and cancer stromal cells on relapse risk and survival after curative gastrectomy in gastric cancer...
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NIRS’s Project for the Reconstruction of Early Internal Dose to Inhabitants in Fukushima After the Nuclear Disaster
In 2012, National Institute of Radiological Sciences (NIRS) launched a project on the reconstruction of the early internal dose, namely the thyroid dose to inhabitants in Fukushima and adjacent prefectures fro...
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Article
Open AccessNIRS external dose estimation system for Fukushima residents after the Fukushima Dai-ichi NPP accident
The great east Japan earthquake and subsequent tsunamis caused Fukushima Dai-ichi Nuclear Power Plant (NPP) accident. National Institute of Radiological Sciences (NIRS) developed the external dose estimation s...
