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Article
Open AccessMultiomics analysis of cultured mouse periodontal ligament cell-derived extracellular matrix
A comprehensive understanding of the extracellular matrix (ECM) is essential for develo** biomimetic ECM scaffolds for tissue regeneration. As the periodontal ligament cell (PDLC)-derived ECM has shown poten...
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Article
Open AccessDNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle
Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and translational efficiency control tissue-dominant protein produc...
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Article
Open AccessRPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function
Although several ribosomal protein paralogs are expressed in a tissue-specific manner, how these proteins affect translation and why they are required only in certain tissues have remained unclear. Here we sho...
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Article
Open AccessHSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis
Transcriptional regulation by RNA polymerase II is associated with changes in chromatin structure. Activated and promoter-bound heat shock transcription factor 1 (HSF1) recruits transcriptional co-activators, ...
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Article
Genetic population structure of Japanese sardinella Sardinella zunasi around Japan
The population structure of Japanese sardinella Sardinella zunasi around Japan was examined based on complete nucleotide sequences of the mitochondrial control region. Phylogenetic analyses revealed four major li...
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Article
Open AccessA phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the ...
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Article
Open AccessCell cycle–dependent localization of the proteasome to chromatin
An integrative understanding of nuclear events including transcription in normal and cancer cells requires comprehensive and quantitative measurement of protein dynamics that underlie such events. However, the...
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Article
Open AccessA shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific metabolic changes remains unclear. Here we show, using the comprehensive measurement of metabolic enzymes by large-scale tar...
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Article
A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen
Whereas large T antigen (LT) of simian virus 40 (SV40) promotes oncogenesis by inactivating the tumor suppressor proteins p53 and pRb, SV40 small T antigen (ST) has been thought to be dispensable for this proc...
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Article
Open AccessThe role of Mediator and Little Elongation Complex in transcription termination
Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes. Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment of Super Elongation Complex (S...
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Article
Is surgical parent artery occlusion effective for intracranial aneurysms measuring over 10 mm in size? Result from long-term follow-up of size changes and outcomes
There have been no long-term follow-up reports pertaining to chronological size changes in large or giant unruptured intracranial aneurysms treated with surgical parent artery occlusion (PAO). The object of th...
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Article
Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16
Multipotent progenitor cells confirm their T cell–lineage identity in the CD4–CD8– double-negative (DN) pro-T cell DN2 stages, when expression of the essential transcription factor Bcl11b begins. In vivo and in v...
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Article
A large-scale targeted proteomics assay resource based on an in vitro human proteome
A large-scale resource, iMPAQT, provides multiple reaction monitoring (MRM)–mass spectrometry assays for targeted quantitative analysis of mTRAQ-labeled human proteins.
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Article
mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide
The polypeptide SPAR is encoded by a long non-coding RNA, localizes to the late endosome and lysosome, and regulates muscle regeneration by inhibiting mTORC1.
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Article
Open AccessAkt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
Th2 cells produce Th2 cytokines such as IL-4, IL-5 and IL-13, but repress Th1 cytokine IFNγ. Recent studies have revealed various distinct memory-type Th2 cell subsets, one of which produces a substantial amou...
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A Study of a Development of Internal Exposure Management Tool Suited for Japanese Diet Behavior
After the Fukushima Nuclear Power Plant accident, one of the main issues at stake was the potential intake of contaminated foodstuff by residents of the affected areas. In this context, the importance of the m...
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Article
Open AccessTissue-specific expression of histone H3 variants diversified after species separation
The selective incorporation of appropriate histone variants into chromatin is critical for the regulation of genome function. Although many histone variants have been identified, a complete list has not been c...
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Article
Overexpression of Ephrin A2 receptors in cancer stromal cells is a prognostic factor for the relapse of gastric cancer
Microenvironments control cancer growth and progression. We explored the prognostic impact of stromal reaction and cancer stromal cells on relapse risk and survival after curative gastrectomy in gastric cancer...
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Article
Lateral basal approach with a supine, no-retractor method for microvascular decompression for hemifacial spasm
We describe the details of our unique surgical procedures for microvascular decompression for hemifacial spasm.
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Article
Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy
