11 Result(s)
within
Masaki Matsumoto
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessMultiomics analysis of cultured mouse periodontal ligament cell-derived extracellular matrix
A comprehensive understanding of the extracellular matrix (ECM) is essential for develo** biomimetic ECM scaffolds for tissue regeneration. As the periodontal ligament cell (PDLC)-derived ECM has shown poten...
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Article
Open AccessDNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle
Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and translational efficiency control tissue-dominant protein produc...
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Article
Open AccessRPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function
Although several ribosomal protein paralogs are expressed in a tissue-specific manner, how these proteins affect translation and why they are required only in certain tissues have remained unclear. Here we sho...
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Article
Open AccessHSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis
Transcriptional regulation by RNA polymerase II is associated with changes in chromatin structure. Activated and promoter-bound heat shock transcription factor 1 (HSF1) recruits transcriptional co-activators, ...
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Article
Open AccessA phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the ...
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Article
Open AccessCell cycle–dependent localization of the proteasome to chromatin
An integrative understanding of nuclear events including transcription in normal and cancer cells requires comprehensive and quantitative measurement of protein dynamics that underlie such events. However, the...
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Article
Open AccessA shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific metabolic changes remains unclear. Here we show, using the comprehensive measurement of metabolic enzymes by large-scale tar...
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Article
Open AccessThe role of Mediator and Little Elongation Complex in transcription termination
Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes. Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment of Super Elongation Complex (S...
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Article
mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide
The polypeptide SPAR is encoded by a long non-coding RNA, localizes to the late endosome and lysosome, and regulates muscle regeneration by inhibiting mTORC1.
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Article
Open AccessAkt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
Th2 cells produce Th2 cytokines such as IL-4, IL-5 and IL-13, but repress Th1 cytokine IFNγ. Recent studies have revealed various distinct memory-type Th2 cell subsets, one of which produces a substantial amou...
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Article
Open AccessNIRS external dose estimation system for Fukushima residents after the Fukushima Dai-ichi NPP accident
The great east Japan earthquake and subsequent tsunamis caused Fukushima Dai-ichi Nuclear Power Plant (NPP) accident. National Institute of Radiological Sciences (NIRS) developed the external dose estimation s...
