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  1. Article

    Open Access

    Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5

    The use of shRNAs to downregulate the expression of specific genes is now relatively routine in experimentation but still hypothetical for clinical application. A potential therapeutic approach for HIV-1 disea...

    Saki Shimizu, Masakazu Kamata, Panyamol Kittipongdaja… in Genetic Vaccines and Therapy (2009)

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  2. No Access

    Article

    A shared neural ensemble links distinct contextual memories encoded close in time

    A similar neural ensemble participates in the encoding of two distinct memories, resulting in the recall of one memory increasing the likelihood of recalling the other, but only if those memories occur very cl...

    Denise J. Cai, Daniel Aharoni, Tristan Shuman, Justin Shobe, Jeremy Biane… in Nature (2016)

  3. No Access

    Article

    Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice

    Approximately 15–40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are widely successfu...

    **g Wen, Di Wu, Meng Qin, Chaoyong Liu, Lan Wang, Duo Xu… in Nature Biomedical Engineering (2019)

  4. No Access

    Article

    CCR5 closes the temporal window for memory linking

    Real-world memories are formed in a particular context and are often not acquired or recalled in isolation1–5. Time is a key variable in the organization of memories, as events that are experienced close in time ...

    Yang Shen, Miou Zhou, Denise Cai, Daniel Almeida Filho, Giselle Fernandes… in Nature (2022)