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Article
Redefining common and rare HTRA1 variants as risk factors for polyvascular disease
Rare and common variants in HTRA1 are associated with ischemic stroke. Research now sheds light on the underlying genetic architecture and suggests a vasculopathy with a broader phenotypic spectrum. Lower HTRA1 p...
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Article
Molecular biomarkers for vascular cognitive impairment and dementia
As disease-specific interventions for dementia are being developed, the ability to identify the underlying pathology and dementia subtypes is increasingly important. Vascular cognitive impairment and dementia ...
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Article
P-wave terminal force in lead V1 and atrial fibrillation burden in cryptogenic stroke with implantable loop recorders
Implantable loop recorders (ILRs) are useful for the detection of atrial fibrillation (AF) in patients with cryptogenic stroke (CS). P-wave terminal force in lead V1 (PTFV1) is associated with AF detection; howev...
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Article
Dedicated transthoracic echocardiography to identify apical thrombus causing recurrent cerebral embolism: a case report
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Article
Open AccessER stress induced immunopathology involving complement in CADASIL: implications for therapeutics
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by NOTCH3 mutations. Typical CADASIL is characterised by subcortical ischemic strokes due to severe a...
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Article
Transcriptomic map** of the human cerebrovasculature
The mechanistic contribution of cerebrovascular dysfunction to neurodegenerative diseases is difficult to determine. New single-cell transcriptomic analyses of human brain microvessels have identified transcri...
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Article
Open AccessAuthor Correction: Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Correction to: Field Assessment of Critical Stroke by Emergency Services for Acute Delivery to a Comprehensive Stroke Center: FACE2AD
The original version of this article unfortunately contained mistakes.
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Article
Early recurrent ischemic events after mechanical thrombectomy: effect of post-treatment intracranial hemorrhage
Patients with intracranial hemorrhages (ICH) after mechanical thrombectomy (MT) may have a higher risk of early recurrent embolism (ERE) because of delayed initiation of anticoagulants. We assessed the rate of...
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Article
Open AccessDifferent aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke
The detection of underlying atrial fibrillation (AF) has become increasingly possible by insertable cardiac monitoring (ICM). During hospitalization for cryptogenic stroke, factors related to the early and lat...
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Article
Open AccessPerlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice
The extracellular matrix fragment perlecan domain V is neuroprotective and functionally restorative following experimental stroke. As neurogenesis is an important component of chronic post-stroke repair, and p...
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Article
Open AccessA case of hemichorea in RNF213-related vasculopathy
Internal carotid artery (ICA) stenosis has been recently reported to cause hemichorea, mainly in East Asia. The East Asian-specific p.R4810K variant of RNF213, a susceptibility gene for moyamoya disease (MMD), ac...
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Article
Open AccessMid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study
We investigated the potential of mid-regional pro-adrenomedullin (MR-proADM) for use as a novel biomarker for arterial stiffness as the criterion for vascular failure and cardiometabolic disease (obesity, hype...
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Article
Open AccessA Prospective Longitudinal Study on the Relationship Between Glucose Fluctuation and Cognitive Function in Type 2 Diabetes: PROPOSAL Study Protocol
Although the risk of dementia among patients with type 2 diabetes mellitus (T2DM) is double that of those without T2DM, the mechanism remains to be elucidated and the glycemic goal to prevent progression of co...
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Article
Various head rotations for ultrasonographic diagnosis of bilateral bow hunter’s syndrome
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Article
Field Assessment of Critical Stroke by Emergency Services for Acute Delivery to a Comprehensive Stroke Center: FACE2AD
Patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) should be triaged to an endovascular-capable hospital by the emergency medical service (EMS). We designed a prehospital LVO predict...
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Article
Underlying embolic and pathologic differentiation by cerebral microbleeds in cryptogenic stroke
Cryptogenic stroke encompasses diverse emboligenic mechanisms and pathogeneses. Cerebral microbleeds (CMBs) occur differently among stroke subtypes. The association of CMBs with cryptogenic stroke is essential...
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Article
Open AccessHuman iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of the most common forms of hereditary cerebral small vessel diseases and is caused by mutations in NOTC...
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Article
Open AccessStatin treatment can reduce incidence of early seizure in acute ischemic stroke: A propensity score analysis
A previous study showed early statin administration in patients with acute ischemic stroke (AIS) was associated with a lower risk of early-onset seizure (ES), which is a high risk of epilepsy, but this retrosp...
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Article
Improved quantification of amyloid burden and associated biomarker cut-off points: results from the first amyloid Singaporean cohort with overlap** cerebrovascular disease
The analysis of the [11C]PiB-PET amyloid images of a unique Asian cohort of 186 participants featuring overlap** vascular diseases raised the question about the validity of current standards for amyloid quantif...
