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Article
Open AccessYellow fever control: current epidemiology and vaccination strategies
Yellow fever (YF) outbreaks continue, have expanded into new areas and threaten large populations in South America and Africa. Predicting where epidemics might occur must take into account local mosquito popul...
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Article
Open AccessRNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
The development of multiple organ dysfunction syndrome (MODS) following infection or tissue injury is associated with increased patient morbidity and mortality. Extensive cellular injury results in the release...
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Article
Open AccessExtracellular release of virulence factor major surface protease via exosomes in Leishmania infantum promastigotes
The Leishmania spp. protozoa are introduced into humans through a sand fly blood meal, depositing the infectious metacyclic promastigote form of the parasite into human skin. Parasites enter a variety of host cel...
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Article
Epidemiology, Prevention, and Potential Future Treatments of Sexually Transmitted Zika Virus Infection
While mosquitoes have been primarily responsible for outbreaks of Zika virus worldwide, most prominently in the Americas during 2015 and 2016, there has been increased recognition of the importance of sexual t...
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Article
Open AccessNlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
The inbred mouse strain C57BL/6J is widely used in models of immunological and infectious diseases. Here we show that C57BL/6J mice have a defect in neutrophil recruitment to a range of inflammatory stimuli co...
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Article
Open AccessDynamics of sterol synthesis during development of Leishmania spp. parasites to their virulent form
The Leishmania spp. protozoa, the causative agents of the “neglected” tropical disease leishmaniasis, are transmitted to mammals by sand fly vectors. Within the sand fly, parasites transform from amastigotes to p...
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Article
NLR proteins and parasitic disease
Parasitic diseases are a serious global health concern. Many of the most common and most severe parasitic diseases, including Chagas’ disease, leishmaniasis, and schistosomiasis, are also classified as neglect...
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Article
Eosinophils and mast cells in leishmaniasis
Leishmania spp. are parasitic protozoa endemic in tropical and subtropical regions and the causative agent of leishmaniasis, a collection of syndromes whose clinical manifestations vary a...
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Article
Common variants in the HLA-DRB1–HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis
Jenefer Blackwell, Peter Donnelly and colleagues report a genome-wide association study for visceral leishmaniasis using studies from India and Brazil, with replication in an additional Indian study. They iden...
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Recent Developments in the Interactions Between Caveolin and Pathogens
The role of caveolin and caveolae in the pathogenesis of infection has only recently been appreciated. In this chapter, we have highlighted some important new data on the role of caveolin in infections due to ...
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Article
Open AccessResistance of Leishmania (Viannia) braziliensis to nitric oxide: correlation with antimony therapy and TNF-α production
Nitric oxide (NO) produced in macrophages plays a pivotal role as a leishmanicidal agent. A previous study has demonstrated that 20% of the L. (V.) braziliensis isolated from initial cutaneous lesions of patients...
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Article
Japanese encephalitis: New vaccines
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Clinical trials report
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Article
Open AccessResistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensisto nitric oxide correlates with disease severity in Tegumentary Leishmaniasis
Nitric oxide (NO•) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO• resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases.
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Evidence for the Existence of a Surface Receptor(s) for Ferriclactoferrin and Ferrictransferrin Associated with the Plasma Membrane of the Protozoan Parasite Leishmania donovani
Previous work has demonstrated the ability of the promastigote form of the protozoan parasite Leishmania chagasi to utilize iron chelated to lactoferrin and transferrin for growth and metabolism. We have obtai...
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Chapter
Specific Binding of Ferrilactoferrin and Ferritransferrin in the Protozoan Leishmania chagasi
Previous work from our laboratory demonstrated that the promastigote form of the parasite Leishmania chagasi, the cause of South American visceral leishmaniasis, can grow in media containing Fe in the form of hem...
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Chapter
Macrophage Receptors and Leishmania
Leishmania are obligate intracellular parasites of mammalian macrophages. The protozoa cause a spectrum of diseases, the characteristics of which vary depending on the species of the parasite and...
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Article
Radiologic findings in hemorrhagic colitis due toEscherichia coli 0157:H7
Hemorrhagic colitis due toEscherichia coli 0157:H7 is a distinct clinical entity characterized by abdominal pain, watery diarrhea progressing to bloody diarrhea, and little or no fever. It has been reported to ha...
