21 Result(s)

Article

Correction: Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

The original version of this Article omitted the following from the Acknowledgements: This research was also supported by grants to KZ (UL and L-CNRS). This has now been corrected in both the PDF and HTML vers...

Farah Kouzi, Kazem Zibara, Jerome Bourgeais, Frederic Picou, Nathalie Gallay… in Oncogene (2020)

Article

Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

The bone marrow (BM) niche impacts the progression of acute myeloid leukemia (AML) by favoring the chemoresistance of AML cells. Intimate interactions between leukemic cells and BM mesenchymal stromal cells (B...

Farah Kouzi, Kazem Zibara, Jerome Bourgeais, Frederic Picou, Nathalie Gallay… in Oncogene (2020)

Article

Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness

Our ability to manage acute myeloid leukemia (AML) is limited by our incomplete understanding of the epigenetic disruption central to leukemogenesis, including improper histone methylation. Here we examine 16 ...

Meaghan Boileau, Margret Shirinian, Tenzin Gayden… in Nature Communications (2019)

Article

The HTLV-1 oncoprotein Tax is modified by the ubiquitin related modifier 1 (Urm1)

Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic human T-cell lymphotropic virus 1 infection, triggered by the virally encoded oncoprotein Tax. The transforming activity an...

Rita Hleihel, Behzad Khoshnood, Ingrid Dacklin, Hayssam Omran… in Retrovirology (2018)

Article

Ki-67 expression predicts biochemical recurrence after radical prostatectomy in the setting of positive surgical margins

Positive surgical margin (PSM) is a predictor of biochemical recurrence (BCR) following radical prostatectomy (RP). Attempts to stratify PSM based on linear length, Gleason score, location and number have fail...

Mohammed Shahait, Samer Nassif, Hani Tamim, Deborah Mukherji, Maya Hijazi… in BMC Urology (2018)

Article

Chemosensitivity of MCF-7 cells to eugenol: release of cytochrome-c and lactate dehydrogenase

Phytochemicals have been extensively researched for their potential anticancer effects. In previous study, direct exposure of rat liver mitochondria to eugenol main ingredient of clove, uncoupled mitochondria ...

Rana Al Wafai, Warde El-Rabih, Meghri Katerji, Remi Safi… in Scientific Reports (2017)

Article

ATL-derived exosomes modulate mesenchymal stem cells: potential role in leukemia progression

Exosomes are membrane nano-vesicles secreted by a multitude of cells that harbor biological constituents such as proteins, lipids, mRNA and microRNA. Exosomes can potentially transfer their cargo to other cell...

Jamal El-Saghir, Farah Nassar, Nadim Tawil, Marwan El-Sabban in Retrovirology (2016)

Article

Reciprocal communication between mesenchymal stem cells and leukemic cells: role of junctional complexes and exosomes in adult T-cell leukemia progression

Jamal El-Saghir, Tala Kanson, Farah Kouzi, Marwa Hussein, Marwan El-Sabban in Retrovirology (2015)

Article

Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo

Cancer cells secrete VEGF, which plays a key role in their growth, invasion, extravasation and metastasis. Direct cancer cell-endothelial cell interaction, mediated by gap junctions, is of critical importance ...

Kazem Zibara, Zahraa Awada, Leila Dib, Jamal El-Saghir… in Scientific Reports (2015)

Article

Antioxidant activity of pomegranate juice reduces acute lung injury secondary to hyperoxia in an animal model

Hyperoxia triggers the release of toxic reactive oxygen species (ROS). Pomegranate Juice (PJ) is a rich source of potent antioxidants. We assessed the effects of PJ supplementation on Acute Lung Injury (ALI) i...

Ahmad Husari, Aline Khayat, Hala Bitar, Yasmine Hashem… in BMC Research Notes (2014)

Article

The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway

Although tumor hypoxia poses challenges against conventional cancer treatments, it provides a therapeutic target for hypoxia-activated drugs. Here, we studied the effect of the hypoxia-activated synthetic quin...

Khaled Ghattass, Sally El-Sitt, Kazem Zibara, Saide Rayes… in Molecular Cancer (2014)

Article

Hetero-cellular interaction between cancer cells and stem cells in cancer metastasis

Jamal El Saghir, Ali Bazarbachi, Youmna Kfoury, Marwan El-Sabban in Retrovirology (2011)

Article

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

Youmna Kfoury, Niclas Setterblad, Marwan El-Sabban, Alessia Zamborlini… in Retrovirology (2011)

Article

Apoptosis and the activity of ceramide, Bax and Bcl-2 in the lungs of neonatal rats exposed to limited and prolonged hyperoxia

The aim of the study is to examine the effect of limited and prolonged hyperoxia on neonatal rat lung. This is done by examining the morphologic changes of apoptosis, the expression of ceramide, an important m...

Ahmad W Husari, Ghassan S Dbaibo, Hala Bitar, Aline Khayat… in Respiratory Research (2006)

Article

Modulation of Ceramide Content and Lack of Apoptosis in the Chronically Hypoxic Neonatal Rat Heart

To assess the effect of chronic hypoxia on cardiomyocyte apoptosis, we used an animal model that mimics cyanotic heart disease. Rats were placed in a hypoxic environment at birth, and oxygen levels were mainta...

Fadi F Bitar, Hala Bitar, Marwan El Sabban, Michael Nasser… in Pediatric Research (2002)