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Article
Open AccessSelf-reported caffeine consumption miss-matched consumption measured by plasma levels of caffeine and its metabolites: results from two population-based studies
Self-reported caffeine consumption has been widely used in research while it may be subject to bias. We sought to investigate the associations between self-reported caffeine consumption and plasma levels of ca...
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Article
Open AccessRunning in the FAMILY: understanding and predicting the intergenerational transmission of mental illness
Over 50% of children with a parent with severe mental illness will develop mental illness by early adulthood. However, intergenerational transmission of risk for mental illness in one’s children is insufficien...
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Article
Open AccessAssociations between antipsychotics-induced weight gain and brain networks of impulsivity
Given the unpredictable rapid onset and ubiquitous consequences of weight gain induced by antipsychotics, there is a pressing need to get insights into the underlying processes at the brain system level that w...
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Article
Open AccessEvaluating the clinical utility of an easily applicable prediction model of suicide attempts, newly developed and validated with a general community sample of adults
A suicide attempt (SA) is a clinically serious action. Researchers have argued that reducing long-term SA risk may be possible, provided that at-risk individuals are identified and receive adequate treatment. ...
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Article
Open AccessSpatial analysis of 10-year predicted risk and incident atherosclerotic cardiovascular disease: the CoLaus cohort
Whether cardiovascular risk scores geographically aggregate and inform on spatial development of atherosclerotic cardiovascular diseases (ASCVD) remains unknown. Our aim is to determine the spatial distributio...
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Article
Open AccessCorrelates of chronic depression in the general population: results from the CoLaus|PsyCoLaus study
Previous population-based studies have partially provided inconsistent results regarding the co-variates of chronic depression, which were likely to be attributable to methodological limitations. The present p...
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Article
Open AccessHow ambient temperature affects mood: an ecological momentary assessment study in Switzerland
Recent research has suggested that an increase in temperature can negatively affect mental health and increase hospitalization for mental illness. It is not clear, however, what factors or mechanisms mediate t...
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Article
Open AccessTopography of associations between cardiovascular risk factors and myelin loss in the ageing human brain
Our knowledge of the mechanisms underlying the vulnerability of the brain’s white matter microstructure to cardiovascular risk factors (CVRFs) is still limited. We used a quantitative magnetic resonance imagin...
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Article
Open AccessPsychotic features, particularly mood incongruence, as a hallmark of severity of bipolar I disorder
The occurrence of psychotic features within mood episodes in patients with bipolar I disorder (BD I) has been associated in some studies with a more severe clinical and socio-professional profile. In contrast,...
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Article
Open AccessSleep spindles in people with schizophrenia, schizoaffective disorders or bipolar disorders: a pilot study in a general population-based cohort
Sleep spindles have been involved in sleep stabilization and sleep-related memory mechanisms and their deficit emerged as possible biomarker in schizophrenia. However, whether this sleep phenotype is also pres...
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Article
Open AccessThe personality traits activity, self-reproach, and negative affect jointly predict clinical recurrence, depressive symptoms, and low quality of life in inflammatory bowel disease patients
The bidirectional “gut-brain axis” has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). While the influence of stress and depressive symptoms on IBD is well-characterized, the role of ...
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Article
Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis
Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants robustly associated with the trait have not been identified. The present study by the Broad Antisocial Behavior Cons...
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Article
Open AccessCYP2C19 expression modulates affective functioning and hippocampal subiculum volume—a large single-center community-dwelling cohort study
Given controversial findings of reduced depressive symptom severity and increased hippocampus volume in CYP2C19 poor metabolizers, we sought to provide empirical evidence from a large-scale single-center longi...
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Article
Healthcare use for major depressive disorders among middle-aged and older adults in the community
There is a substantial gap between people having a mental disorder and those treated for this disorder. Studies that assessed the influence of age on healthcare use for major depressive disorder (MDD) have pro...
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Article
Open AccessEnvironmental factors in offspring of parents with mood disorders and their role in parent–child transmission: findings from a 14-year prospective high-risk study
The factors involved in the transmission of mood disorders are only partially elucidated. Aside from genes, the family environment might play a crucial role in parent–child transmission. Our goals were to (1) ...
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Article
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk
Studies in post-mortem human brain tissue have associated major depressive disorder (MDD) with cortical transcriptomic changes, whose potential in vivo impact remains unexplored. To address this translational ...
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Article
Open AccessDiurnal Salivary Cortisol in Sarcopenic Postmenopausal Women: The OsteoLaus Cohort
Sarcopenia, similar to hypercortisolism, is characterized by loss of muscle mass and strength. Cortisol circadian rhythm changes with aging (blunted late-day nadir values) were suggested to contribute to this ...
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Article
Open AccessObesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts
Studies considering the causal role of body mass index (BMI) for the predisposition of major depressive disorder (MDD) based on a Mendelian Randomization (MR) approach have shown contradictory results. These i...
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Article
Minimal phenoty** yields genome-wide association signals of low specificity for major depression
Minimal phenoty** refers to the reliance on the use of a small number of self-reported items for disease case identification, increasingly used in genome-wide association studies (GWAS). Here we report diffe...
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Article
Hay Fever is Associated with Prevalence, Age of Onset and Persistence of Stuttering
Atopic diseases and adverse childhood experiences are associated with neurodevelopmental disorders including developmental stuttering. This study examined the associations between these factors and lifetime pr...
