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Article
Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be p...
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Article
White matter abnormalities across the lifespan of schizophrenia: a harmonized multi-site diffusion MRI study
Several prominent theories of schizophrenia suggest that structural white matter pathologies may follow a developmental, maturational, and/or degenerative process. However, a lack of lifespan studies has precl...
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Chapter and Conference Paper
Pairwise, Ordinal Outlier Detection of Traumatic Brain Injuries
Because mild Traumatic Brain Injuries (mTBI) are heterogeneous, classification methods perform outlier detection from a model of healthy tissue. Such a model is challenging to construct. Instead, we utilize re...
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Article
The white matter query language: a novel approach for describing human white matter anatomy
We have developed a novel method to describe human white matter anatomy using an approach that is both intuitive and simple to use, and which automatically extracts white matter tracts from diffusion MRI volum...
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Article
Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy
Subcaudate tractotomy (SCT) is a neurosurgical lesioning procedure that can reduce symptoms in medically intractable obsessive compulsive disorder (OCD). Due to the putative importance of the orbitofrontal cor...
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Article
Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing
Deficits in the execution of a sequence of movements are common in schizophrenia. Previous studies reported reduced functional activity in the motor cortex and cerebellum in schizophrenic patients with deficit...
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Chapter and Conference Paper
On Describing Human White Matter Anatomy: The White Matter Query Language
The main contribution of this work is the careful syntactical definition of major white matter tracts in the human brain based on a neuroanatomist’s expert knowledge. We present a technique to formally describ...
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Chapter and Conference Paper
White Matter Bundle Registration and Population Analysis Based on Gaussian Processes
This paper proposes a method for the registration of white matter tract bundles traced from diffusion images and its extension to atlas generation. Our framework is based on a Gaussian process representation o...
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Chapter and Conference Paper
Shape Modeling and Analysis with Entropy-Based Particle Systems
This paper presents a new method for constructing compact statistical point-based models of ensembles of similar shapes that does not rely on any specific surface parameterization. The method requires very lit...
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Chapter and Conference Paper
Logarithm Odds Maps for Shape Representation
The concept of the Logarithm of the Odds (LogOdds) is frequently used in areas such as artificial neural networks, economics, and biology. Here, we utilize LogOdds for a shape representation that demonstrates ...
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Chapter and Conference Paper
Discriminative MR Image Feature Analysis for Automatic Schizophrenia and Alzheimer’s Disease Classification
We construct a computational framework for automatic central nervous system (CNS) disease discrimination using high resolution Magnetic Resonance Images (MRI) of human brains. More than 3000 MR image features ...
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Chapter and Conference Paper
Automating segmentation of dual-echo MR head data
Multiecho MR acquisition yields various information about tissue and csf characteristics. The analysis of two-dimensional scatterplots generated from dual-echo MR data turns out to be a useful tool. It allows ...