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Article
Open AccessPolygenic Hypercholesterolemia and Cardiovascular Disease Risk
Identification of loci and common single-nucleotide polymorphisms (SNPs) that have modest effects on plasma lipids have been used to confirm or refute the causal role of lipid traits in the development of coron.....
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Article
Open AccessGenetic Architecture of Familial Hypercholesterolaemia
Familial hypercholesterolaemia (FH) is an inherited disorder of low-density lipoprotein cholesterol (LDL-C) which is characterised by a raised cholesterol level from birth and a high risk of premature coronary...
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Article
Erratum: A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans
Nature Communications 5: Article number: 4871 (2015); Published 16 September 2014; Updated 12 May 2015 During the production of this Article, errors were introduced in the frequencies of the variants rs964184-...
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Article
Open AccessA rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans
The analysis of rich catalogues of genetic variation from population-based sequencing provides an opportunity to screen for functional effects. Here we report a rare variant in APOC3 (rs138326449-A, minor allele ...