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  1. No Access

    Article

    Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates

    The most common chemogenetic neuromodulatory system, designer receptors exclusively activated by designer drugs (DREADDs), uses a non-endogenous actuator ligand to activate a modified muscarinic acetylcholine ...

    Nicholas A. Upright, Mark G. Baxter in Neuropsychopharmacology (2020)

  2. No Access

    Article

    Memories light the corners of my mind

    Using light-activated ion channels to stimulate sensory and motivational pathways, Vetere and colleagues constructed fully artificial memories in mice. Mice preferred or avoided an odor they had never smelled ...

    Mark G. Baxter, Nicholas A. Upright in Nature Neuroscience (2019)

  3. No Access

    Article

    Cell- and layer-specific transcriptomic strategy for characterizing the molecular phenotype of rat cortical neurons using laser capture microdissection and massively parallel RNA sequencing

    Michael L. Miller, Benjamin Chadwick, Dara L. Dickstein… in Molecular Psychiatry (2019)

  4. Article

    Open Access

    Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons

    Neuronal circuits within the prefrontal cortex (PFC) mediate higher cognitive functions and emotional regulation that are disrupted in psychiatric disorders. The PFC undergoes significant maturation during ado...

    Michael L. Miller, Benjamin Chadwick, Dara L. Dickstein… in Molecular Psychiatry (2019)

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  5. Article

    Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse

    Attention is disrupted commonly in psychiatric disorders, yet mechanistic insight remains limited. Deficits in this function are associated with dorsal anterior cingulate cortex (dACC) excitotoxic lesions and ...

    Hiroyuki Koike, Michael P Demars, Jennifer A Short… in Neuropsychopharmacology (2016)

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  6. No Access

    Article

    Behavioral control by the orbital prefrontal cortex: reversal of fortune

    A study shows that selective lesions of the orbital prefrontal cortex in macaques spare behavioral flexibility and emotional processing but impair a test of outcome expectation, suggesting that some psychiatri...

    Mark G Baxter, Paula L Croxson in Nature Neuroscience (2013)

  7. No Access

    Article

    The ageing cortical synapse: hallmarks and implications for cognitive decline

  8. Individual differences are a hallmark of cognitive and synaptic ageing. Neurobiological differences between individuals of the same chronological age may under...

    9. John H. Morrison, Mark G. Baxter in Nature Reviews Neuroscience (2012)

  9. No Access

    Article

    Cholinergic modulation of a specific memory function of prefrontal cortex

    Deficits in prefrontal cholinergic function have been implicated in cognitive impairment in many neuropsychiatric diseases. Here, the authors report that monkeys with lesions of cholinergic input to prefrontal...

    Paula L Croxson, Diana A Kyriazis, Mark G Baxter in Nature Neuroscience (2011)

  10. No Access

    Article

    Activation of 5-HT6 receptors facilitates attentional set shifting

    Prefrontal cortex (PFC)-dependent executive function is disrupted in a range of psychiatric disorders and can be modelled in non-human primates and rodents using attentional set-shifting paradigms. There are f...

    Katherine E. Burnham, Mark G. Baxter, John R. Bainton, Eric Southam… in Psychopharmacology (2010)

  11. No Access

    Chapter

    Age-Related Effects on Prefrontal Cortical Systems: Translating Between Rodents, Nonhuman Primates, and Humans

    Impairments in cognition related to dysfunction of the prefrontal cortex occur as a consequence of aging in rodents, nonhuman primates, and humans. This chapter describes evidence from several different cognit...

    Mark G. Baxter in Animal Models of Human Cognitive Aging (2009)

  12. No Access

    Article

    The amygdala and reward

  13. It is widely accepted that the amygdala is associated with fear conditioning and the processing of negative emotions. But this structure is also involved in th...

    14. Mark G. Baxter, Elisabeth A. Murray in Nature Reviews Neuroscience (2002)