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Article
Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates
The most common chemogenetic neuromodulatory system, designer receptors exclusively activated by designer drugs (DREADDs), uses a non-endogenous actuator ligand to activate a modified muscarinic acetylcholine ...
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Article
Memories light the corners of my mind
Using light-activated ion channels to stimulate sensory and motivational pathways, Vetere and colleagues constructed fully artificial memories in mice. Mice preferred or avoided an odor they had never smelled ...
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Article
Cell- and layer-specific transcriptomic strategy for characterizing the molecular phenotype of rat cortical neurons using laser capture microdissection and massively parallel RNA sequencing
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Article
Open AccessAdolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons
Neuronal circuits within the prefrontal cortex (PFC) mediate higher cognitive functions and emotional regulation that are disrupted in psychiatric disorders. The PFC undergoes significant maturation during ado...
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Article
Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse
Attention is disrupted commonly in psychiatric disorders, yet mechanistic insight remains limited. Deficits in this function are associated with dorsal anterior cingulate cortex (dACC) excitotoxic lesions and ...
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Article
Behavioral control by the orbital prefrontal cortex: reversal of fortune
A study shows that selective lesions of the orbital prefrontal cortex in macaques spare behavioral flexibility and emotional processing but impair a test of outcome expectation, suggesting that some psychiatri...
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Article
The ageing cortical synapse: hallmarks and implications for cognitive decline
Individual differences are a hallmark of cognitive and synaptic ageing. Neurobiological differences between individuals of the same chronological age may under...
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Article
Cholinergic modulation of a specific memory function of prefrontal cortex
Deficits in prefrontal cholinergic function have been implicated in cognitive impairment in many neuropsychiatric diseases. Here, the authors report that monkeys with lesions of cholinergic input to prefrontal...
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Article
The amygdala and reward
It is widely accepted that the amygdala is associated with fear conditioning and the processing of negative emotions. But this structure is also involved in th...