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Article
Memories light the corners of my mind
Using light-activated ion channels to stimulate sensory and motivational pathways, Vetere and colleagues constructed fully artificial memories in mice. Mice preferred or avoided an odor they had never smelled ...
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Article
Behavioral control by the orbital prefrontal cortex: reversal of fortune
A study shows that selective lesions of the orbital prefrontal cortex in macaques spare behavioral flexibility and emotional processing but impair a test of outcome expectation, suggesting that some psychiatri...
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Article
The ageing cortical synapse: hallmarks and implications for cognitive decline
Individual differences are a hallmark of cognitive and synaptic ageing. Neurobiological differences between individuals of the same chronological age may under...
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Article
Cholinergic modulation of a specific memory function of prefrontal cortex
Deficits in prefrontal cholinergic function have been implicated in cognitive impairment in many neuropsychiatric diseases. Here, the authors report that monkeys with lesions of cholinergic input to prefrontal...
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Article
The amygdala and reward
It is widely accepted that the amygdala is associated with fear conditioning and the processing of negative emotions. But this structure is also involved in th...