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Article
Open AccessPARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy
Personalized cancer therapy relies on identifying patient subsets that benefit from a therapeutic intervention and suggest alternative regimens for those who don’t. A new data integrative approach, based on gr...
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Article
Open AccessMicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603
Carboplatin/paclitaxel (CP), with or without sorafenib, result in objective response rates of 18–20 % in unselected chemotherapy-naïve patients. Molecular predictors of survival and response to CP-based chemot...
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Protocol
Strategies for Measurement of Biotransformation Enzyme Gene Expression
The analysis of gene expression is an integral part of any gene function research. A wide variety of techniques have been developed for this purpose, each with its own advantages and limitations. The following...
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Protocol
Genoty** Technologies: Application to Biotransformation Enzyme Genetic Polymorphism Screening
Pharmacogenomics encompasses several major areas: the study of polymorphic variations to drug response and disease susceptibility, identification of the effects of drugs/xenobiotics at the genomic level, and g...
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Protocol
Pharmacogenomics
Pharmacogenomics encompasses several major areas including the identification and analysis of variations of DNA and RNA that affect the efficacy and toxicity of drug therapy. It represents an integration of an...
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Reference Work Entry In depth
Pharmacogenomics
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Protocol
Strategies for Measurement of Biotransformation Enzyme Gene Expression
The analysis of gene expression is an integral part of any research characterizing gene function. A wide variety of techniques have been developed for this purpose, each with their own advantages and limitatio...
-
Protocol
Genoty** Technologies
Pharmacogenomics encompasses several major areas: the study of polymorphic variations in drug response and disease susceptibility, identification of the effects of drugs/xenobiotics at the genomic level, and g...
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Article
A Potential Role for the Estrogen-metabolizing Cytochrome P450 Enzymes in Human Breast Carcinogenesis
Purpose. The cytochrome P450 (CYP) enzymes play a critical role in the oxidative metabolism of a variety of endogenous and exogenous compounds, including drugs. Although intermediate CYP metabolites are believed...
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Article
All-trans-retinoic acid modulation of drug-metabolizing enzyme activities: investigation with selective metabolic drug probes
Purpose: All-trans-retinoic acid (ATRA) is a retinoid analogue that has been shown to be effective in acute promyelocytic leukemia. It is currently being investigated for efficacy in the treatment and prevention...
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Article
NAT2 Genetic Polymorphism in Child Liver Disease. • 471
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GSTM1 NULL POLYMORPHISM AT THE GLUTATHIONE S-TRANSFERASE M1 LOCUS IN CHILDHOOD LIVER DISEASE. • 253
