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  1. Article

    Open Access

    Antifibrogenic and apoptotic effects of Ocoxin in cultured rat hepatic stellate cells

    Ocoxin is a nutritional supplement that has been shown to exert antioxidant and immunomodulatory responses in patients with chronic hepatitis C. The present work aimed to determine the effects of Ocoxin on act...

    Marina Ruiz de Galarreta, Elena Arriazu… in Journal of Physiology and Biochemistry (2023)

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  2. No Access

    Article

    WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. β-Catenin (CTNNB1)-mutated HCC represents 30% of cases of the disease with no precision therapeutics available. Using chemical...

    Alex Rialdi, Mary Duffy, Alex P. Scopton, Frank Fonseca, Julia Nanyi Zhao… in Nature Cancer (2023)

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    Article

    Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma

    Atezolizumab (anti-programmed death-ligand 1 (PD-L1)) and bevacizumab (anti-vascular endothelial growth factor (VEGF)) combination therapy has become the new standard of care in patients with unresectable hepa...

    Andrew X. Zhu, Alexander R. Abbas, Marina Ruiz de Galarreta… in Nature Medicine (2022)

  4. Article

    Open Access

    NASH limits anti-tumour surveillance in immunotherapy-treated HCC

    Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stra...

    Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere… in Nature (2021)

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  5. Article

    Erratum: DNA sensing in senescence

    Nature Cell Biology 19, 1008–1009 (2017); published online 31 August 2017; corrected after print 30 October 2017. In the original version of this News and Views, the name of author Marina Ruiz de Galarreta was...

    Marina Ruiz de Galarreta, Amaia Lujambio in Nature Cell Biology (2017)

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  6. No Access

    Article

    DNA sensing in senescence

    Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS–STING DNA-se...

    Marina Ruiz de Galarreta, Amaia Lujambio in Nature Cell Biology (2017)