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  1. No Access

    Article

    Contradictory intrahepatic immune responses activated in high-load hepatitis C virus livers compared with low-load livers

    We found a HLA class II histocompatibility antigen gene, DQ alpha 1 chain (HLA-DQA1), that was expressed more than 9-fold higher in high-load hepatitis C virus (HCV) livers than low-load HCV livers using transcri...

    Mariko Ishibashi, Hiromi Yamaguchi, Yukari Hirotani… in Archives of Virology (2018)

  2. Article

    Open Access

    Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium

    Patients with tongue cancer frequently show loss of heterozygosity (LOH) of the von Hippel–Lindau (VHL) tumor suppressor gene. However, expression of VHL protein (pVHL) in tongue cancer has rarely been investigat...

    Hisashi Hasegawa, Yoshiaki Kusumi, Takeshi Asakawa, Miyoko Maeda… in BMC Cancer (2017)

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  3. Article

    CLEC4M-positive and CD81-negative Huh7 cells are not susceptible to JFH-1 HCVcc infection but mediate transinfection

    C-type lectin domain family 4, member M (CLEC4M), a trans-membrane protein specifically expressed in liver sinusoidal endothelial cells, is considered a candidate receptor for hepatotropism of hepatitis C virus (...

    Mariko Ishibashi, Naoko Morita, Chisato Nomura-Kawaguchi… in Archives of Virology (2014)

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  4. No Access

    Article

    Expression profiles of interferon gamma genes in response to immunostimulants and alloantigen in ginbuna crucian carp Carassius auratus langsdorfii

    Interferon gamma (IFNγ), a Th1-derived cytokine is one of the key molecules inducing cell-mediated immune responses in mammals. The expression of 2 distinct IFNγ (ifng1 and ifng2) and IFNγrel (ifngrel) genes was ...

    Kyosuke Araki, Fumio Takizawa, Masatoshi Yamasaki, Mariko Esumi… in Fisheries Science (2013)

  5. Article

    Open Access

    A mutation at IVS1 + 5 of the von Hippel-Lindau gene resulting in intron retention in transcripts is not pathogenic in a patient with a tongue cancer?: case report

    Von Hippel-Lindau disease (VHL) is a dominantly inherited familial cancer syndrome predisposing the patient to a variety of malignant and benign neoplasms, most frequently hemangioblastoma, renal cell carcinom...

    Takeshi Asakawa, Mariko Esumi, Sohei Endo, Akinori Kida… in BMC Medical Genetics (2012)

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  6. No Access

    Article

    Clonal state of human hepatocellular carcinoma and non-tumorous hepatocytes

    We determined the clonal state in specimens of hepatocellular carcinoma (HCC) and non-tumorous hepatocytes from the integration mode of hepatitis B virus (HBV) DNA. The integration mode of HBV DNA in several p...

    Mariko Esumi, Yuji Tanaka, Shinji Tozuka… in Cancer Chemotherapy and Pharmacology (1989)