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  1. No Access

    Article

    Tumor infiltrating lymphocytes as adjuvant treatment in stage III melanoma patients with only one invaded lymph node after complete resection: results from a multicentre, randomized clinical phase III trial

    Adoptive tumor-infiltrating lymphocytes (TIL) therapy and interleukin-2 (IL-2) have been investigated in melanoma.

    Amir Khammari, Jean-Michel Nguyen, Marie-Thérèse Leccia… in Cancer Immunology, Immunotherapy (2020)

  2. No Access

    Article

    Adoptive T cell therapy combined with intralesional administrations of TG1042 (adenovirus expressing interferon-γ) in metastatic melanoma patients

    Tumor immune escape has recently been shown to be related to the development of an immune tolerance state of the microenvironment. Cytokines activating the immune system such as IFN-γ can be used to reverse t...

    Amir Khammari, Jean-Michel Nguyen, Melanie Saint-Jean… in Cancer Immunology, Immunotherapy (2015)

  3. Article

    Open Access

    Value of large scale expansion of tumor infiltrating lymphocytes in a compartmentalised gas-permeable bag: interests for adoptive immunotherapy

    Adoptive cell therapy (ACT) has emerged as an effective treatment for patients with metastatic melanoma. However, there are several logistical and safety concerns associated with large-scale ex vivo expansion of ...

    Thomas Zuliani, Julien David, Sylvain Bercegeay… in Journal of Translational Medicine (2011)

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  4. Article

    Long-term follow-up of patients treated by adoptive transfer of melanoma tumor-infiltrating lymphocytes as adjuvant therapy for stage III melanoma

    The first analysis of our clinical trial on interest of using tumor-infiltrating lymphocytes (TIL) as adjuvant therapy for stage III (regional lymph nodes) melanoma was published in 2002 [5]. The aim of this pape...

    Amir Khammari, Jean-Michel Nguyen… in Cancer Immunology, Immunotherapy (2007)

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  5. No Access

    Article

    Infusion of Melan-A/Mart-1 specific tumor-infiltrating lymphocytes enhanced relapse-free survival of melanoma patients

    Adoptive therapy of cancer has been mostly tested in advanced cancer patients using tumor-infiltrating lymphocytes (TIL). Following discouraging results likely due to poor tumor-specificity of TIL and/or high ...

    Houssem Benlalam, Virginie Vignard, Amir Khammari… in Cancer Immunology, Immunotherapy (2007)

  6. No Access

    Article

    Therapeutic efficacy of melanoma-reactive TIL injected in stage III melanoma patients

    Adoptive therapy for cancer using tumor-infiltrating lymphocytes (TIL) has mainly been investigated in cancer patients with advanced stage disease. The limited clinical success has not been encouraging, altho...

    Nathalie Labarrière, Marie-Christine Pandolfino… in Cancer Immunology, Immunotherapy (2002)

  7. No Access

    Article

    High-scale expansion of melanoma-reactive TIL by a polyclonal stimulus: predictability and relation with disease advancement

     The rationale of treating melanoma patients by infusion with tumor-infiltrating leukocytes (TIL) is to perform an adoptive therapy through injection of tumor-specific T cells. Nonetheless, methods currently u...

    Marie-Christine Pandolfino, Nathalie Labarrière… in Cancer Immunology, Immunotherapy (2001)