8 Result(s)
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Article
The COL6A5-p.Glu2272* mutation induces chronic itch in mice
Pruritus is a common irritating sensation that provokes the desire to scratch. Environmental and genetic factors contribute to the onset of pruritus. Moreover, itch can become a major burden when it becomes ch...
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Article
A resource of targeted mutant mouse lines for 5,061 genes
The International Mouse Phenoty** Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter a...
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Article
Open AccessTargeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models
Gene copy number variants play an important role in the occurrence of neurodevelopmental disorders. Particularly, the deletion of the 16p11.2 locus is associated with autism spectrum disorder, intellectual dis...
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Article
Open AccessModeling human disease in rodents by CRISPR/Cas9 genome editing
Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is n...
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Article
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics
Steve Brown and colleagues report an analysis of 20 phenoty** tests, including 413 data parameters, across 449 mutant mouse alleles. They identify widespread pleiotropy and assign putative functions to genes...
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Article
Open AccessThe mammalian gene function resource: the international knockout mouse consortium
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 y...
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Article
Open AccessMouse large-scale phenoty** initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project
Two large-scale phenoty** efforts, the European Mouse Disease Clinic (EUMODIC) and the Wellcome Trust Sanger Institute Mouse Genetics Project (SANGER-MGP), started during the late 2000s with the aim to deliv...
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Protocol
Site-Specific Recombinases for Manipulation of the Mouse Genome
Site-specific recombination systems are widespread and popular tools for all scientists interested in manipulating the mouse genome. In this chapter, we focus on the use of site-specific recombinases (SSR) to ...
