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Article
Genetic chasing of T helper cell idiotype and allotype genes
The present experiments were performed to study whether the genes responsible for the expression of T-cell idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Us...
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Article
A new member of the immunoglobulin superfamily—CTLA-4
The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains1,2. It includes s...
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Article
Proximity of the CTLA-1 serine esterase and Tcr α loci in mouse and man
The serine esterase CTLA-1 gene was shown by in situ hybridization to map to the D segment of mouse chromosome 14, the same localization as a member of the immunoglobulin super family, Tcr α. To further demonstra...