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  1. Article

    Open Access

    Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

    Broad-spectrum RAS inhibition has the potential to benefit roughly a quarter of human patients with cancer whose tumours are driven by RAS mutations1,2. RMC-7977 is a highly selective inhibitor of the active GTP-...

    Urszula N. Wasko, **g**g Jiang, Tanner C. Dalton, Alvaro Curiel-Garcia… in Nature (2024)

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  2. No Access

    Article

    Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication

    The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma. However, approximate...

    Johanna Theruvath, Marie Menard, Benjamin A. H. Smith, Miles H. Linde… in Nature Medicine (2022)