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  1. Article

    Open Access

    Substance use disorder of equimolar oxygen-nitrous oxide mixture in French sickle-cell patients: results of the PHEDRE study

    In many countries, nitrous oxide is used in a gas mixture (EMONO) for short-term analgesia. Cases of addiction, with significant misuse, have been reported in hospitalized patients. Patients suffering from sic...

    Marie Gérardin, Morgane Rousselet, Marie-Laure Couec… in Orphanet Journal of Rare Diseases (2024)

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  2. Article

    Open Access

    Evolution of the Addictovigilance Signal of Zopiclone: A 2014–2020 National Follow-up Study

    Zopiclone, like zolpidem, is under surveillance in France due to its potential for dependence, abuse and misuse. However, part of the narcotics regulation was implemented in 2017 in France for zolpidem only, w...

    Aurélie Aquizerate, Edouard-Jules Laforgue… in International Journal of Mental Health and… (2023)

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  3. Article

    Open Access

    PHEDRE trial protocol – observational study of the prevalence of problematic use of Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) and analgesics in the French sickle-cell disease population

    The use of analgesics can lead to cases of drug abuse and dependence. It can also cause pseudo-addiction in patients suffering from pain. What is the actual situation in patients suffering from severe sickle-c...

    Marie Gérardin, Marie-Laure Couec, Marie Grall-Bronnec, Fanny Feuillet… in BMC Psychiatry (2015)

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