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Open AccessThe MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276
The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in t...
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Regulation of transcriptional activators by DNA-binding domain ubiquitination
Ubiquitin is a key component of the regulatory network that maintains gene expression in eukaryotes, yet the molecular mechanism(s) by which non-degradative ubiquitination modulates transcriptional activator (...
