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  1. Article

    Open Access

    Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase

    Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) play a central role in tryptophan metabolism and are involved in many cellular and disease processes. Here we report the crystal structure...

    Ariel Lewis-Ballester, Farhad Forouhar, Sung-Mi Kim, Scott Lew… in Scientific Reports (2016)

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  2. Article

    Open Access

    CHIP−/−-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications

    Genetic ablation of C-terminus of Hsc70-interacting protein (CHIP) E3 ubiquitin-ligase impairs hepatic cytochrome P450 CYP2E1 degradation. Consequent CYP2E1 gain of function accelerates reactive O2 species (ROS) ...

    Sung-Mi Kim, James P. Grenert, Cam Patterson, Maria Almira Correia in Scientific Reports (2016)

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