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Article
Open AccessSubacute administration of both methcathinone and manganese causes basal ganglia damage in mice resembling that in methcathinone abusers
An irreversible extrapyramidal syndrome occurs in man after intravenous abuse of “homemade” methcathinone (ephedrone, Mcat) that is contaminated with manganese (Mn) and is accompanied by altered basal ganglia ...
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Article
Open AccessHigh correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats
6-Hydroxydopamine (6-OHDA) is widely used in pre-clinical animal studies to induce degeneration of midbrain dopamine neurons to create animal models of Parkinson's disease. The aim of our study was to evaluate...
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Chapter
In Vivo Biodistribution Studies and Cell Tracking in Stroke Using SPECT Imaging
The recent advances in stem cell research have given stroke patients new hope. Early clinical trials seem to be feasible and safe, although therapeutic effects are only marginal so far. One possible reason for...
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Article
Open AccessAdvanced brain dopamine transporter imaging in mice using small-animal SPECT/CT
Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively...
