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Article
Open AccessEvaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol
Rapamycin is an inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, and preclinical data demonstrate that it is a promising candidate for a general gero- and neuroprotective treatment in hu...
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Article
Open AccessOn Perturbation of Operators and Rayleigh-Schrödinger Coefficients
Let A and E be self-adjoint matrices or operators on \(\ell ^2({{\mathbb {N}}})\) ...
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Article
Open AccessPrognostic utility and characterization of left ventricular hypertrophy using global thickness
Cardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, and several measures related to LV wall thickness exist. We hypothesized that prognosis can be used to select an optim...
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Article
Open AccessIn vivo hepatic flow distribution by computational fluid dynamics can predict pulmonary flow distribution in patients with Fontan circulation
In Fontan patients, a lung deprived of hepatic blood may develop pulmonary arterio-venous malformations (PAVMs) resulting in shunting, reduced pulmonary vascular resistance (PVR) and decreased oxygenation. To ...
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Article
Open AccessHemodynamic forces from 4D flow magnetic resonance imaging predict left ventricular remodeling following cardiac resynchronization therapy
Patients with heart failure and left bundle branch block (LBBB) may receive cardiac resynchronization therapy (CRT), but current selection criteria are imprecise, and many patients have limited treatment respo...
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Article
Open AccessCorrection: Right ventricular longitudinal function is linked to left ventricular filling pressure in patients with repaired tetralogy of Fallot
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Open AccessRight ventricular longitudinal function is linked to left ventricular filling pressure in patients with repaired tetralogy of fallot
Experimental data on pulmonary regurgitation has linked right ventricular longitudinal function to left ventricular filling pressure in animals with induced and treated pulmonary regurgitation but this relatio...
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Article
Open AccessDeep learning can yield clinically useful right ventricular segmentations faster than fully manual analysis
Right ventricular (RV) volumes are commonly obtained through time-consuming manual delineations of cardiac magnetic resonance (CMR) images. Deep learning-based methods can generate RV delineations, but few stu...
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Article
Open AccessIncreased biventricular hemodynamic forces in precapillary pulmonary hypertension
Precapillary pulmonary hypertension (PHprecap) is a condition with elevated pulmonary vascular pressure and resistance. Patients have a poor prognosis and understanding the underlying pathophysiological mechanism...
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Article
Open AccessInfarct quantification with cardiovascular magnetic resonance using "standard deviation from remote" is unreliable: validation in multi-centre multi-vendor data
The objective of the study was to investigate variability and agreement of the commonly used image processing method “n-SD from remote” and in particular for quantifying myocardial infarction by late gadoliniu...
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Article
Open AccessQuantitative myocardial perfusion during stress using CMR is impaired in healthy Middle Eastern immigrants without CV risk factors
Middle Eastern immigrants constitute a growing proportion of the European population and compared to native Swedes are more insulin resistant, which can contribute to atherosclerosis. Quantitative first pass p...
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Article
Open AccessAtrioventricular plane displacement and regional function to predict outcome in pulmonary arterial hypertension
To investigate if left and right atrioventricular plane displacement (AVPD) or regional contributions to SV are prognostic for outcome in patients with pulmonary arterial hypertension (PAH). Seventy-one patien...
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Article
Correction to: Computational Fluid Dynamics Support for Fontan Planning in Minutes, Not Hours: The Next Step in Clinical Pre-Interventional Simulations
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Open AccessComputational Fluid Dynamics Support for Fontan Planning in Minutes, Not Hours: The Next Step in Clinical Pre-Interventional Simulations
Computational fluid dynamics (CFD) modeling may aid in planning of invasive interventions in Fontan patients. Clinical application of current CFD techniques is however limited by complexity and long computatio...
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Article
Open AccessNon-invasive quantification of pressure–volume loops in patients with Fontan circulation
Pressure–volume (PV) loops provide comprehensive information of cardiac function, but commonly implies an invasive procedure under general anesthesia. A novel technique has made it possible to non-invasively e...
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Article
Open AccessBias Versus Non-Convexity in Compressed Sensing
Cardinality and rank functions are ideal ways of regularizing under-determined linear systems, but optimization of the resulting formulations is made difficult since both these penalties are non-convex and dis...
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Article
Open AccessValidation and quantification of left ventricular function during exercise and free breathing from real-time cardiac magnetic resonance images
Exercise cardiovascular magnetic resonance (CMR) can unmask cardiac pathology not evident at rest. Real-time CMR in free breathing can be used, but respiratory motion may compromise quantification of left vent...
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Article
Open AccessHemodynamic force analysis is not ready for clinical trials on HFpEF
Hemodynamic force analysis has been proposed as a novel tool for early detection of subclinical systolic dysfunction in heart failure with preserved ejection fraction (HFpEF). Here we investigated the ability ...
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Article
Open AccessAnterior STEMI associated with decreased strain in remote cardiac myocardium
To assess (1) global longitudinal strain (GLS) by feature tracking cardiac magnetic resonance (CMR) in the sub-acute and chronic phases after ST-elevation infarction (STEMI) and compare to GLS in healthy contr...
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Cardiovascular Simulation as a Decision Support Tool
The variable presentation of clinical disease in pediatric patients with congenital and acquired heart disease makes standardized care challenging. This is further enforced by the ongoing growth and remodeling...
