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Article
Aneurysmal bone cyst-like changes developed in melorheostosis with epiphyseal osteopoikilosis
Aneurysmal bone cyst (ABC) is a rare and usually painful condition, representing about 1% of all bone tumors. A geographical lytic, expansile, and septated radiological pattern, with fluid–fluid levels on MRI,...
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Article
A reduction in tumor volume exceeding 65% predicts a good histological response to neoadjuvant chemotherapy in patients with Ewing sarcoma
No consensus exists for tumor volume response criteria in patients with Ewing sarcoma. This study aimed to identify an optimal cutoff for predicting a good histological response by analyzing tumor volume chang...
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Article
Histological and imaging features of myoepithelial carcinoma of the bone and soft tissue
To depict histological and imaging features of myoepithelial carcinoma of the bone and soft tissue.
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Article
Open AccessSecondary peripheral chondrosarcoma in multiple osteochondromas: a retrospective single-institution case series
Multiple osteochondromas is genetic disorder characterized by the formation of multiple benign cartilage-capped bone tumors, named osteochondromas, during skeletal development. The most feared complication is ...
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Article
Open AccessA novel patient-derived immortalised cell line of myxofibrosarcoma: a tool for preclinical drugs testing and the generation of near-patient models
Myxofibrosarcoma is a rare malignant soft tissue sarcoma characterised by multiple local recurrence and can become of higher grade with each recurrence. Consequently, myxofibrosarcoma represents a burden for p...
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Article
Does PAX7 and NKX2.2 immunoreactivity in Ewing sarcoma have prognostic significance?
Ewing sarcoma (ES) is an aggressive neoplasm with variable morphology. It has no specific immunoprofile or molecular signature. Neither CD99, NKX2.2 nor PAX7 immunoreactivity alone is completely specific, alth...
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Article
Open AccessSecondary peripheral chondrosarcoma arising in solitary osteochondroma: variables influencing prognosis and survival
Secondary peripheral chondrosarcomas arising in solitary osteochondromas is an unusual complication, reported in small series. In this study, we aimed to present our experience with this rare variant of chondr...
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Article
Usefulness of β-catenin expression in the differential diagnosis of osteosarcoma, osteoblastoma, and chondroblastoma
The aim of this study is to assess the usefulness of beta-catenin immunohistochemical expression in the differential diagnosis of osteoid-producing primary tumors of bone. Seventy cases of osteoid-producing tu...
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Article
Lipoblastoma-like tumor of the spermatic cord: case report and review of the literature
Lipoblastoma-like tumor is a very rare mesenchymal tumor believed to be restricted to female patients and only recently reported in the spermatic cord of a male patient. We describe herein an additional case o...
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Article
Open AccessMalignancy in giant cell tumor of bone: analysis of an open-label phase 2 study of denosumab
Giant cell tumor of bone (GCTB) is a rare osteoclastogenic stromal tumor. GCTB can rarely undergo malignant transformation. This post hoc analysis evaluated and classified malignancies in patients with GCTB wh...
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Article
Vertebroplasty shows no antitumoral effect on vertebral metastasis: a case-based study on anatomopathological examinations
Percutaneous vertebroplasty (VTP) is a well-known surgical technique used for pain management and vertebral consolidation in the treatment of osteolytic metastases of the spine.
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Article
Denosumab in the treatment of giant cell tumor of the spine. Preliminary report, review of the literature and protocol proposal
The interest on the role of Denosumab in the treatment strategy of giant cell tumor of the spine is growing. En bloc resection is considered the Enneking appropriate treatment, but morbidity and functional los...
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Chapter
Classification of Primary Bone Lesions
Primary bone tumors are classified on the base of their histological differentiation, as reported in the following table. Thay are divided into “benign” (with a limited capacity of local recurrence), “intermed...
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Living Reference Work Entry In depth
Knuckle Pads
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Living Reference Work Entry In depth
Elastofibroma
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Living Reference Work Entry In depth
Ganglion Cyst
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Chapter
Neurofibromas
Definition: Benign tumor of the peripheral nerve sheath. (a) Solitary. (b) Multiple in neurofibromatosis type 1 (NF1).
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Chapter
Metastatic Lesions
Definition: Secondary localization in bone of malignant epithelial neoplasm.
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Chapter
Molecular Alterations in Musculoskeletal Lesions
The marriage of molecular genetics and soft tissue tumor pathology certainly represents one of the most fruitful events of the last decade. The close relationship between morphology (including immunohistochemi...
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Chapter
Schwannoma
Definition: Nerve sheath tumor composed of differentiated neoplastic Schwann cells.
