65 Result(s)

Article

Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-α antibody

The role of tumor necrosis factor-α in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four h...

Jaap Jansen, Tom van der Poll, Marcel Levi, Hugo ten Cate… in Journal of Clinical Immunology (1995)

Article

Acute hepatitis in a patient using a Chinese herbal tea ‐ a case report.

A case is presented of reversible acute hepatitis in a patient using a Chinese herbal tea. Upon identification of the tea mixture Aristolochia species, including A. debilis, which contains the highly toxic ari...

Marcel Levi, Henk‐Jan Guchelaar, Herman J. Woerdenbag… in Pharmacy World and Science (1998)

Article

Current Drug Treatment Strategies for Disseminated Intravascular Coagulation

Disseminated intravascular coagulation (DIC) can be caused by a variety of diseases. Experimental models of DIC have provided substantial insight into the pathogenesis of this disorder, which may ultimately re...

Dr Evert de Jonge, Marcel Levi, Christiaan P. Stoutenbeek… in Drugs (1998)

Article

Fibrinogen-coated albumin microcapsules reduce bleeding in severely thrombocytopenic rabbits

Severe thrombocytopenia frequently occurs in patients receiving chemotherapy and in patients with autoimmune disorders. Thrombocytopenia is associated with bleeding, which may be serious and life threatening^1,2,3

Marcel Levi, Philip W. Friederich, Sarah Middleton, Philip G. de Groot… in Nature Medicine (1999)

Article

Pathogenesis of DIC in Sepsis

Sepsis can be associated with profound alterations in the hemostatic mechanism. In this article we discuss recent insights into which mediators are involved in the activation of the coagulation system. We focu...

Tom van der Poll, Evert de Jonge, Marcel Levi, Sander J.H. van Deventer in Sepsis (1999)

Article

Relative Insufficiency of the Fibrinolytic System in Disseminated Intravascular Coagulation

Experimental and clinical observations indicate that the systemic deposition of fibrin in disseminated intravascular coagulation (DIC) is insufficiently counteracted by endogenous fibrinolysis. In fact, a mark...

Marcel Levi, Tom van der Poll, Evert de Jonge, Hugo ten Cate in Sepsis (1999)

Article

Mouse models of focal arterial and venous thrombosis

Mouse models of arterial and venous thrombosis have gained increasing interest over the last 15 years, due to direct availability of a growing number of genetically modified mice, improved technical feasibili...

Janine Dörffler-Melly, Lothar A. Schwarte, Can Ince… in Basic Research in Cardiology (2000)

Chapter

Hemostasis and Coagulation

Bleeding is one of the major complications of surgery. Serious intraoperative and postoperative bleeding may be caused by a local problem in surgical hemostasis, such as a failed ligature, but can also be caus...

Marcel Levi, Tom van der Poll in Surgery (2001)

Chapter

Coagulation and Fibrinolysis During Endotoxemia and Gram-Negative Sepsis

Severe gram-negative infections are sometimes associated with the clinical syndrome of disseminated intravascular coagulation (DIC). The derangement of the hemostatic mechanism not only comprises enhanced acti...

Tom Van Der Poll, Marcel Levi, Sander J. H. Van Deventer in Physiology of Inflammation (2001)

Article

Drotrecogin Alfa (Activated)

Marcel Levi in Drugs (2002)

Chapter

Hemostasis and Coagulation

Marcel Levi, Tom van der Poll in Essential Practice of Surgery (2003)

Article

Treatment with recombinant human activated protein C obviates additional anticoagulation during continuous venovenous hemofiltration in patients with severe sepsis

Anne Cornélie J. M. de Pont, Catherine S. C. Bouman… in Intensive Care Medicine (2003)

Article

Sepsis and Disseminated Intravascular Coagulation

Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation (DIC). There is compelling evidence from clinical and ...

Marcel Levi, Evert de Jonge, Tom van der Poll in Journal of Thrombosis and Thrombolysis (2003)

Article

Prevention and Treatment of Bleeding by Pro-hemostatic Treatment Strategies

Pro-hemostatic therapy may achieve an improvement of hemostasis, by amelioration of primary hemostasis, stimulation of fibrin formation or inhibition of fibrinolysis. Pro-hemostatic interventions appear to be ...

Marcel Levi, Roel Vink, Evert de Jonge in Wiener Medizinische Wochenschrift (2003)

Article

Prescription of rh-APC differs substantially among western European countries

Marcus J. Schultz, Marcel Levi in Intensive Care Medicine (2006)