36 Result(s)

Article

Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines

It is generally accepted that a coagulation/fibrinolysis disorder is involved in the pathogenesis of sepsis, and the association of disseminated intravascular coagulation (DIC) and poor outcomes have been repo...

Toshiaki Iba, Osamu Nishida, Jerrold H. Levy, Marcel Levi in Journal of Intensive Care (2022)

Article

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe disease show hyperactivation of the immune...

Aldo Bonaventura, Alessandra Vecchié, Lorenzo Dagna… in Nature Reviews Immunology (2021)

Article

COVID-19 coagulopathy: is it disseminated intravascular coagulation?

One of the significant complications of severe COVID-19 infections is a coagulopathy that seems to be related to the occurrence of venous and arterial thromboembolic disease. The coagulation changes mimic but ...

Marcel Levi, Toshiaki Iba in Internal and Emergency Medicine (2021)

Article

Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Jim Aitken, Karen Ambrose, Sam Barrell, Rupert Beale… in Nature Biotechnology (2020)

Article

Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken, Karen Ambrose, Sam Barrell, Rupert Beale… in Nature Biotechnology (2020)

Article

The unique characteristics of COVID-19 coagulopathy

Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulo...

Toshiaki Iba, Jerrold H. Levy, Jean Marie Connors, Theodore E. Warkentin… in Critical Care (2020)

Article

Strengths and weaknesses of the acute care systems in the United Kingdom and the Netherlands: what can we learn from each other?

The demand on Emergency Departments and acute medical services is increasing internationally, creating pressure on health systems and negatively influencing the quality of delivered care. Visible consequences ...

Marjolein N. T. Kremers, Prabath W. B. Nanayakkara, Marcel Levi… in BMC Emergency Medicine (2019)

Chapter

Erratum behorend bij: ‘De dokter en het geld’

Marcel Levi in De dokter en het geld (2018)

Article

What do sepsis-induced coagulation test result abnormalities mean to intensivists?

Marcel Levi, Marcus J. Schultz in Intensive Care Medicine (2017)

Article

Management of bleeding in patients treated with direct oral anticoagulants

Recently, a new generation of direct-acting oral anticoagulants (DOACs) with a greater specificity towards activated coagulation factors was introduced based on encouraging results for efficacy and safety in c...

Marcel Levi in Critical Care (2016)

Article

Another step in improving the diagnosis of disseminated intravascular coagulation in sepsis

The diagnosis of disseminated intravascular coagulation (DIC) based on composite scoring systems using routinely available coagulation tests has been greatly facilitated. Such scoring instruments not only adeq...

Marcel Levi in Critical Care (2013)

Article

Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study

Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. Protease-activated receptor-1 (PAR-1) is expressed by multiple cell types present in the lungs and can be activated ...

Marcel Schouten, Cornelis van't Veer, Joris JTH Roelofs, Marcel Levi… in Critical Care (2012)

Article

Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome – a retrospective propensity matched cohort study

Acute lung injury (ALI) is characterized by a pro-coagulant state. Heparin is an anticoagulant with anti-inflammatory properties. Unfractionated heparin has been found to be protective in experimental models o...

Jorrit J Hofstra, Alexander P J Vlaar, David J Prins, Gavin Koh… in BMC Pulmonary Medicine (2012)

Article

Nebulized anticoagulants for acute lung injury - a systematic review of preclinical and clinical investigations

Data from interventional trials of systemic anticoagulation for sepsis inconsistently suggest beneficial effects in case of acute lung injury (ALI). Severe systemic bleeding due to anticoagulation may have off...

Pieter R Tuinman, Barry Dixon, Marcel Levi, Nicole P Juffermans… in Critical Care (2012)

Article

Systemic versus localized coagulation activation contributing to organ failure in critically ill patients

In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation not only leads to activati...

Marcel Levi, Tom van der Poll, Marcus Schultz in Seminars in Immunopathology (2012)

Article

Acute Stress Elicited by Bungee Jum** Suppresses Human Innate Immunity

Although a relation between diminished human immunity and stress is well recognized both within the general public and the scientific literature, the molecular mechanisms by which stress alters immunity remain...

David J. van Westerloo, Goda Choi, Ester C. Löwenberg, Jasper Truijen… in Molecular Medicine (2011)

Article

Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study

Blood transfusion is associated with increased morbidity and mortality in cardiac surgery patients, but cause-and-effect relations remain unknown. We hypothesized that blood transfusion is associated with chan...

Pieter R Tuinman, Alexander P Vlaar, Alexander D Cornet, Jorrit J Hofstra… in Critical Care (2011)

Article

Treatment with recombinant human activated protein C: one size does not fit all

Protein C plays an important role in the coagulopathy associated with sepsis and probably also in the pathogenesis of sepsis-induced organ dysfunction. Plasma levels of protein C strongly correlate with clinic...

Marcel Levi in Critical Care (2011)

Article

Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study

Streptococcus (S.) pneumoniae is the most common cause of community-acquired pneumonia. The factor V Leiden (FVL) mutation results in resistance of activated FV to inactivation by activated protein C and thereby ...

Marcel Schouten, Cornelis van't Veer, Joris JTH Roelofs, Marcel Levi… in Critical Care (2010)

Article

2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema

We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angio...

Tom Bowen, Marco Cicardi, Henriette Farkas… in Allergy, Asthma & Clinical Immunology (2010)